ID   A0A239CS58_9RHOB        Unreviewed;       276 AA.
AC   A0A239CS58;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=2,5-diketo-D-gluconate reductase A {ECO:0000313|EMBL:SNS22769.1};
GN   ORFNames=SAMN05421757_101438 {ECO:0000313|EMBL:SNS22769.1};
OS   Tropicimonas sediminicola.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Tropicimonas.
OX   NCBI_TaxID=1031541 {ECO:0000313|EMBL:SNS22769.1, ECO:0000313|Proteomes:UP000198426};
RN   [1] {ECO:0000313|EMBL:SNS22769.1, ECO:0000313|Proteomes:UP000198426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 29339 {ECO:0000313|EMBL:SNS22769.1,
RC   ECO:0000313|Proteomes:UP000198426};
RA   Kim H.J., Triplett B.A.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FZOY01000001; SNS22769.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A239CS58; -.
DR   OrthoDB; 9768793at2; -.
DR   Proteomes; UP000198426; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198426}.
FT   DOMAIN          18..260
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        51
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         109
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            76
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   276 AA;  30138 MW;  79E3F1BC52D48D5B CRC64;
     MTDVPTLPLN DGHSIPQLGF GIWQVPAGTA TGTIRSALEV GYRLIDGAYI YGNEAELGEG
     LRSSGVPRDE VFITTKVWNR DQGRAAARAS VERSLASIGV EQLDLVLIHW PVPSRDLYVE
     TWQALIEMRD EGLMRSIGVS NFNAEHLERI IAETGVVPAL NQIEVNPKLQ QPELRAVNAK
     HGIVTQAWTP LGNARSFEDA PIAEAAARTG KSPAQVVLRW HIQLGNAVIP RSEKPARQAE
     NLDVFDFELT PAEMEAIAGL DIGLRCGPDP SVFRLL
//