ID A0A239E2I9_9ACTN Unreviewed; 832 AA.
AC A0A239E2I9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Mannose-1-phosphate guanylyltransferase / phosphomannomutase {ECO:0000313|EMBL:SNS38837.1};
GN ORFNames=SAMN06265355_11663 {ECO:0000313|EMBL:SNS38837.1};
OS Actinomadura mexicana.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=134959 {ECO:0000313|EMBL:SNS38837.1, ECO:0000313|Proteomes:UP000198420};
RN [1] {ECO:0000313|EMBL:SNS38837.1, ECO:0000313|Proteomes:UP000198420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44485 {ECO:0000313|EMBL:SNS38837.1,
RC ECO:0000313|Proteomes:UP000198420};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231}.
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DR EMBL; FZNP01000016; SNS38837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239E2I9; -.
DR OrthoDB; 9801810at2; -.
DR Proteomes; UP000198420; Unassembled WGS sequence.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05805; MPG1_transferase; 1.
DR CDD; cd04181; NTP_transferase; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR22572:SF15; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 2.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000313|EMBL:SNS38837.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNS38837.1}.
FT DOMAIN 2..233
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 383..512
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 533..633
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 641..740
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
SQ SEQUENCE 832 AA; 89778 MW; E07A2C0B23E55054 CRC64;
MKAVVMAGGE GTRLRPMTAN QPKPLLPLVN RPIMEHVLRL LKKHGFGETV VTVQFLAALI
RNYFGDGEEL GMSLSYATEE VPLGTAGSVK NAEEALRDDR FLVISGDALT DIDLTDMVRF
HEENDALVTI GLKRVPNPLE FGIIIVDDVG RVQRFLEKPT WGQVFSDTVN TGIYVMEPEV
LEHVAEGEPV DWSADVFPKL LAEGARLFGY VADCYWEDVG THESYLKAQA DMLSGQVGID
LDGFEMSPGV WVAEGAEVDA EAILKGPLYI GDYAKVEAGV ELREFTVLGS NVVVKEGAFL
HRAVVHDNVF VAPSTNLRGC VVGKNTDIMA GARVEEGAVI GDECVIEAEA YVSSGVKVYP
FKTIEAGAVV NTSVIWESRG QRNLFGPRGV SGLVNVEITP ELAVRLASAY ATTLKKGTTV
VTGRDVSRAA RTLKRAVNSA LTASAINVQD LEATPLTVAR FETGREDSVG GIYIRTTLGD
PQGVDILFLD ADGADLSQGA QRKLERVFGR QEYRRAFPGE IAELTYPPRV VETYTRDLLR
RVDIRGVREA GLKIVLDCAG GVASLVLPNL LGKVGVEVLT RNAGLDEANP TETLAERMRD
LERLGELVSS SRAAFGVRFD PVGERISLVD ENGELVGDDR ALLVMLDLVA AERRGGKVAL
PVTTTRVAEQ VCRFHGVQVE WTSTSQDVLT KAAAQPSVVF AGDGRGGFLM PEFSGTVDGI
AAFVRLVGLV ARTRLTLSQI DRRIPDAHLL RRSVPTPWAA KGSVMRHVVE AAGNRTLDTT
DGVRVVEGDG RWVLVLPDPA EAVTHLWAEG PDADAAQALL AEWAAVVERA GS
//
