ID A0A239ED19_9MICO Unreviewed; 387 AA.
AC A0A239ED19;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Zn-dependent protease (Includes SpoIVFB) {ECO:0000313|EMBL:SNS42409.1};
GN ORFNames=SAMN06309944_0197 {ECO:0000313|EMBL:SNS42409.1};
OS Micrococcales bacterium KH10.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales.
OX NCBI_TaxID=1945885 {ECO:0000313|EMBL:SNS42409.1, ECO:0000313|Proteomes:UP000198369};
RN [1] {ECO:0000313|EMBL:SNS42409.1, ECO:0000313|Proteomes:UP000198369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH10 {ECO:0000313|EMBL:SNS42409.1,
RC ECO:0000313|Proteomes:UP000198369};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
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DR EMBL; FZPE01000001; SNS42409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239ED19; -.
DR OrthoDB; 9781963at2; -.
DR Proteomes; UP000198369; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR39188; MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B; 1.
DR PANTHER; PTHR39188:SF3; ZINC METALLOPROTEASE SLR1821-RELATED; 1.
DR Pfam; PF02163; Peptidase_M50; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:SNS42409.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000313|EMBL:SNS42409.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198369};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..134
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
FT DOMAIN 140..192
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
SQ SEQUENCE 387 AA; 40984 MW; D3FF53744ABC42F3 CRC64;
MSQRQPLTVT VRQIPVTITA STLIAAVVLA WLFWPTWHQL LGISVAGAVA IAAAKVLIYL
LSILGHEVAH AVVGRMLGRT VSYIRLTALG GVTGFERAGS KTAPAKARNG QWLIAAAGPL
ANATFALAWW IIGQVIGTPE SVADLIASDV ARTAAWLNGA LAIFNAIPGL PLDGGQVLVQ
LVQRRGGRPS TALLTGAWAG RATSVIVLVV LIVPALLADG RPHSLRSVWA ILIAMILWQG
ASEALPYART LRAVTDLDPS ALWKSVEVLP PATSMSEFER IAQQHATAEK LMVVGEPTDP
SRWLRLEPQA FQTVPVSARG ATQLSAVSVP LTVAVVQLTG LPSPCEHLLE TSQGAEFIVE
SVGAGSYRGM SGHDLRQWIQ SHVAQAR
//
