ID A0A239ES60_9ACTN Unreviewed; 516 AA.
AC A0A239ES60;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Signal transduction histidine kinase {ECO:0000313|EMBL:SNS47409.1};
GN ORFNames=SAMN06265355_11865 {ECO:0000313|EMBL:SNS47409.1};
OS Actinomadura mexicana.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=134959 {ECO:0000313|EMBL:SNS47409.1, ECO:0000313|Proteomes:UP000198420};
RN [1] {ECO:0000313|EMBL:SNS47409.1, ECO:0000313|Proteomes:UP000198420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44485 {ECO:0000313|EMBL:SNS47409.1,
RC ECO:0000313|Proteomes:UP000198420};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FZNP01000018; SNS47409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239ES60; -.
DR OrthoDB; 3288457at2; -.
DR Proteomes; UP000198420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SNS47409.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..329
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT DOMAIN 377..498
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF02518"
FT REGION 417..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 53852 MW; A6060B033583D6BB CRC64;
MTTDDKARTG PDPAGFGPAV AHHAWRLSGR IVAGVGQLLL WILTGIGTLL RPLAVRLGAR
LNGGAGRGPG APPGQTAPLP RWINTWREVV GAWYFAPLTG LALTIAALAE LAPRVDSPIS
LAGGFAVAAT FPLVWRRENL RAVAAVVLSA VAASLLTGQL LLVTTSFAAL YTLYALGRRL
PRQSTGVLAV GSVAALGVVY LATGTLDDIP WPAPIVAVLA AIGLGDARRV VESAGRTEAE
AAERTNETLT RLTAVQREQA VMRERARIAR ELHDVVAHSV SMIAVQAETA PYTMENLSPE
ARAGYTEIAK TARDALVEMR RLLNVLRADA TPEPEAANSP QPRLDRLPDL IEQHRGAGGH
VDLAVHGDPR ALSTTVELSA YRIVQEALTN ARRHAPGAGV RVDLTFLPDR LAVRVQDNGA
SASTQVLNPR GPGSRTGGPS PAAPPPADAG RTRLEPSGSG GGHGLVGMRE RATMLGGRFS
AGPATQGGFL VQAELPVTSE GNSTRGHGSQ APPGRP
//
