ID A0A239FIZ4_9SPHN Unreviewed; 900 AA.
AC A0A239FIZ4;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN06295912_10964 {ECO:0000313|EMBL:SNS56765.1};
OS Sphingomonas laterariae.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=861865 {ECO:0000313|EMBL:SNS56765.1, ECO:0000313|Proteomes:UP000198281};
RN [1] {ECO:0000313|Proteomes:UP000198281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LNB2 {ECO:0000313|Proteomes:UP000198281};
RA Varghese N., Submissions S.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FZOS01000009; SNS56765.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239FIZ4; -.
DR Proteomes; UP000198281; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198281}.
FT DOMAIN 728..744
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 654..661
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 900 AA; 94376 MW; 963A318892C4CE40 CRC64;
MFGALQSAAF VEGPFGAWLD GGQVAISAAM ARTTNENGGG GANVTPMMAQ YHALKAEAQD
CLLFYRMGDF FELFFDDAKI ASACLDIALT SRGDGVPMCG VPAHSAEGYL ARLIKAGHRV
AIADQTETPA EAKKRGGSKA LVGRAIVRVV TAGTLTEEAL LDARAANWLV ALAEAGGQIG
LAAADISTGR FELAAIPAGS LDAELARLGA AETIAADGFA FAPADAISQD PRAFDSTAGE
ARLKALFGVA TLDSFGGFGR AELAAAAGLL AYLDRAGQGK LPFLQPPARR HPADHMLIDA
ATRDSLELTQ AQGGGRKGSL LDAVDRTVTG AGARMLAADI GAPLAERLVI EARLDLVTRF
VDDGGLRESI RTNLKAAPDI GRAIGRLVAG RGSPRDLGLL RDGLDEAHGL HERLLRLGDR
PALLDQLLPQ MRGHGALIDL LTRALVPQPP IDTAQGGYIA EGYDPALDDL RGQGGEGRRA
IAALEARYRE ATGITSLKIR HNGVLGYHIE VQAKHADPLM RPESGFTHRQ TLAGVVRFNA
PDLHEQALRV GQAGAHALAA EAAHLEELVA AALACKTAIA ATADALARLD VAAGLAERAI
EGHWCRPAFA EEPCFEVEGG RHPVVEAAVT ATGERFVAND CQLLPDRRLW LVTGPNMGGK
STFLRQNALI AVLAQAGGYV PAASARLGLV DRLFSRVGAS DNLARGRSTF MVEMVETAAI
LAQATERSLV ILDEVGRGTS TYDGLAIAWA VVEAVHDINR CRCLFATHYH ELTRLAERLD
ALSLHHVRAR EWKGDLVLLH ELADGPADRS YGIAVAKLAG LPPAVLGRAQ SVLAKLESGR
AATGGIAAGL DDLPLFAAAA AAPPPPVDPL REALDAILPD ALSPRDALDA LYRLKTLAEG
//
