ID A0A239G9S7_9MICO Unreviewed; 867 AA.
AC A0A239G9S7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN06309944_1193 {ECO:0000313|EMBL:SNS65860.1};
OS Micrococcales bacterium KH10.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales.
OX NCBI_TaxID=1945885 {ECO:0000313|EMBL:SNS65860.1, ECO:0000313|Proteomes:UP000198369};
RN [1] {ECO:0000313|EMBL:SNS65860.1, ECO:0000313|Proteomes:UP000198369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH10 {ECO:0000313|EMBL:SNS65860.1,
RC ECO:0000313|Proteomes:UP000198369};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|ARBA:ARBA00006360}.
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DR EMBL; FZPE01000001; SNS65860.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239G9S7; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000198369; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Reference proteome {ECO:0000313|Proteomes:UP000198369};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 36..305
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 389..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 90647 MW; A1016F6DFF01F675 CRC64;
MSQALYRRYR PESFDEVIGQ EHVTGPLMQA LKSGRVNHAY LFSGPRGCGK TTSARILARV
LNCAANTEES PIAVPCGSCE SCMELGRGGS GSLDVVEIDA ASHGGVDDAR DLRERATFSP
SRDRFKIFIL DEAHMVTSAG FNALLKIVEE PPPYLKFIFA TTEPDKVIGT IRSRTHHYPF
RLVPPEVLQP YLEQVCAAEN IVTTPGVLPL VVRAGGGSVR DSLSVLDQLI SGADGNEVSY
EIAAGLLGFT PVTLLDDVVE AVSGQDGAGL FRVVEQVIAT GHEPRRFVED LLERFRDLLV
LKVSGEGGAA VFSSYPADQV ERMGQQAGSL GLAQLSRAAD IINVALTEMT GATSPRLHLE
LLCARLLLPN AESELRSVLA RVENLESGAV TSGRGSVSNV QNAPAGSAAS QQTGRGLTAP
QSTAVVAGPT PEGSAAQPVT ETQPAQAVQP AQTAQSAPQA GQTTQHARTA PRQSPARNNV
DAALAAATRI VREEERSAAP ATAEQTAAAP QAGGVPEPES TPPSTEKQAA PEPQPTPTSP
TSTSEPSASA PSVSGNVTKV ETEVLMRRWD DVLAEVSALR KATWALVKQN ATVGSLDGEV
LTLLFASEGL ASAFKSGTHA QIVAEALSRS LGVTARVTAA VGDLPQAAAA ASTAATPRES
HRQSSSTGSS DEPAAEEPAR PADTEPVPPH DDPPPVADTP QSADEDIPLP PEPDSHDDHN
MVPPLPEAAP VVTEPQATPV PPGNRRSSER PVLPPIPSRR SHNGEKTTEA NSSTANDKAR
TRPWQRGNGD DSTGSTDGRN ESNATGRAAS QRETPSAQSP AEQEAAAEAA WQATDTVELE
DSSLVGAPLI AQILGGVVID EDIEQGD
//
