ID A0A239GKX0_9ACTN Unreviewed; 651 AA.
AC A0A239GKX0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN06893096_106258 {ECO:0000313|EMBL:SNS69809.1};
OS Geodermatophilus pulveris.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Geodermatophilus.
OX NCBI_TaxID=1564159 {ECO:0000313|EMBL:SNS69809.1, ECO:0000313|Proteomes:UP000198373};
RN [1] {ECO:0000313|EMBL:SNS69809.1, ECO:0000313|Proteomes:UP000198373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46839 {ECO:0000313|EMBL:SNS69809.1,
RC ECO:0000313|Proteomes:UP000198373};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FZOO01000006; SNS69809.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239GKX0; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000198373; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..137
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 151..461
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 651 AA; 72020 MW; 8BD071DC78717C19 CRC64;
MTKPDPNFIW SIADLLRGPY RPKEYGTVIL PFTVLARFES VLAPTKKAVL GAAVKYEDSP
PLLRDTMLKR AAGQDFYNTS QVSLSDLGDP SQLAANLINL VDGYNEEVRQ IFERFDMHNV
IRTLDDRDRL PDIVKRFAVL NVHPDLVSNA EMGDVFEELI RRFMESSKDL AGDYFTPREV
VRLCVSLLFS PDTHDLSDPN LIRQVYDPTC GTGGMLSEAH QWMEDHGGQA TLSLYGQEFN
EISHAMAKSD LLIRRQDPRN IYFGDTLLDD GHANKTFTYC LANPPFGQDW KKQQKAVLAE
RARDGESGRF AAGVPSVNDG AMLFLQHLVS KMRPADQGGG RGAIVLNGSP LFAGGAGSGP
SEIRRHLLRN DLVDAIIGLP TQMFYNTGIA TYIWVLDNNK PAERQGKVQL IDATSLWVPM
PKSIGDKRRM LSPANINAIV ALYGEFEDAD PKLSKVLSTE DFGYRTITVE QPLRQVFAVD
DDGINRVMGL RAINKLDKDT RHALREALGS LDQTATWTSL GDFDMALGSA LGGQGVGLTP
ANRRSVTAAF AVSSSEGMLV TDKTGAPEPD PDLRDTENVP LTEDVDAYLK REVLPWAPEA
WIDHSRTKIG YEVPFAKTFY VYQPPRPLAD IDSDVQGAIA RVQALFTEVK A
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