ID   A0A239I3F7_9ACTN        Unreviewed;       407 AA.
AC   A0A239I3F7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN   ORFNames=SAMN05443665_1011106 {ECO:0000313|EMBL:SNS88110.1};
OS   Actinomadura meyerae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=240840 {ECO:0000313|EMBL:SNS88110.1, ECO:0000313|Proteomes:UP000198318};
RN   [1] {ECO:0000313|EMBL:SNS88110.1, ECO:0000313|Proteomes:UP000198318}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44715 {ECO:0000313|EMBL:SNS88110.1,
RC   ECO:0000313|Proteomes:UP000198318};
RA   Kim H.J., Triplett B.A.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC       sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
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DR   EMBL; FZOR01000011; SNS88110.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A239I3F7; -.
DR   Proteomes; UP000198318; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR026335; rSAM_SPASM_FxsB.
DR   InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR   NCBIfam; TIGR04269; SAM_SPASM_FxsB; 1.
DR   PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR   PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR   Pfam; PF13353; Fer4_12; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01072; dehydrogenase_like; 1.
DR   SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198318};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          28..279
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   407 AA;  45222 MW;  D0EC0F1DD8457A27 CRC64;
     MGVRSGEPGS EWPDALDVRA LLEDGWRPTP LRDFILKVHS RCNLACDYCY MYEMADQGWR
     RQPRRMSRQV LEWTAQRIAE HARTNLLSEV QVVLHGGEPL LAGAEHLRHA IEVVRAAVGT
     DAHVGFSVQT NGVLLDEVFL DLFAEYGVMV GVSVDGDEEG HDRHRRRADG RGSYQAVRAG
     LERLTGPRHR HLFGGLLSTI ELRNDPVATY ESLLEFAPPE MDFLLPHGNW DTPPPGRPPD
     ESTPYADWLI AIFDRWYAVE AADVRIRLFS EIIRLLFGRM SGSEAVGLSP VSVVVVETNG
     EIEQVDSLKS AYEGAAGTRL HVSRDPFDTV LALPSVAARQ IGRRALSDQC LACPAHEVCG
     AGLYPHRYRS GTGFRNPSVY CRDLFKLITH IRDVVSRELA AEPVAAG
//