ID A0A239JPJ9_9ACTN Unreviewed; 636 AA.
AC A0A239JPJ9;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:SNT07811.1};
GN ORFNames=SAMN05421812_10363 {ECO:0000313|EMBL:SNT07811.1};
OS Asanoa hainanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Asanoa.
OX NCBI_TaxID=560556 {ECO:0000313|EMBL:SNT07811.1, ECO:0000313|Proteomes:UP000198362};
RN [1] {ECO:0000313|EMBL:SNT07811.1, ECO:0000313|Proteomes:UP000198362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.5593 {ECO:0000313|EMBL:SNT07811.1,
RC ECO:0000313|Proteomes:UP000198362};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FZPH01000003; SNT07811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239JPJ9; -.
DR OrthoDB; 5241017at2; -.
DR Proteomes; UP000198362; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:SNT07811.1};
KW Cell division {ECO:0000313|EMBL:SNT07811.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000198362};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..636
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039156734"
FT DOMAIN 28..139
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 148..314
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 362..630
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 636 AA; 65436 MW; 0CF13B5DAFC8D7FA CRC64;
MTRRPAALLA GLALVAAGLA GCSSDPGPDD AVDSFLSAWK SGDLSQIAFV EPTGSKVAAT
EVQAALKELS GELTPPVVRR EGEPKEVEGS ATAAVDLDWT LPGGTHWTYP STVRLIKGGD
DVWSVIWEPA IVNAKLKSGD QLALRRQRPE RAGILDGAGK PIVEPRDVVV VGVEPAGVDD
PAGIARALDS AFKSVRPALP KIDVSDLPAK INSAEDPEQF LEVVTLRRDA YLQIRSKIQP
LEGTRFREEK RDLAPTRAFA RALLGSADPA LKEDIDKRPD EVAEGDLVGH GGLQGALDKQ
LRGTPGVSVV IANKGPDGEV TDGEELWRSE AKAGTPVKTT LDVSVQNAAD TALSGLRQRS
ALVAVRVSDG AVLAAANGPD GGSGENLAFT AQVPPGSTFK MVSGYGLLSS GKVTATTSVD
CPKTFTVDGR SFKNSENFAL GKVPFQVDFA KSCNTAFASL APSLGDDGLA LAGRALGLEA
KWDLGVDAFS GKVSTGGSAA ERAAAAFGQG TTLVSPLSMA SATASVAKGS AVTPKILADK
PAAGDGAALK AEALGPLKSM MRQVVTSGTA TALKDVPGGA VSGKTGTAEF DDNPAHTHAW
FVGWQGDIAF AVFVENGGGS GTTAVPAAER FIRALH
//
