ID   A0A239K6P3_9SPHN        Unreviewed;       957 AA.
AC   A0A239K6P3;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SAMN06295912_14715 {ECO:0000313|EMBL:SNT14027.1};
OS   Sphingomonas laterariae.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=861865 {ECO:0000313|EMBL:SNT14027.1, ECO:0000313|Proteomes:UP000198281};
RN   [1] {ECO:0000313|Proteomes:UP000198281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LNB2 {ECO:0000313|Proteomes:UP000198281};
RA   Varghese N., Submissions S.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FZOS01000047; SNT14027.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A239K6P3; -.
DR   Proteomes; UP000198281; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SNT14027.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198281};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          327..535
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   957 AA;  106568 MW;  893F96FB36FD24B7 CRC64;
     MTLHTPGAAF EGAEWLFAIG RGGDLPAVDG LVAVDGYVPA GRPPEEVAFI EKAASYGARA
     VFFEAGRHGR ASVAQAFVFD AAAHADDRAF AELHKRLWSW SGVPIVYRAG PGQIQLFRCA
     HAPDFVGPDD TPICRPIRTL AIGAEIAVQD VWWDAARIRN GAIWDDPDAC RLMLSAQKSA
     HRKLVEEVRE LARQMGERRL LDGGLQRRLL ILSLLIAYLE ERSVLLPDDF ARALPGATHF
     FEVLGNGPAL ITLLEALEER FNGHVFRLKD AERAALADST ELASYARLVE GFEDSTGQFS
     LWRLYSFRDL PVELISNIYQ LFVKDAASSI YTPPALVRLM LEETLSWDRI DRLMAGDGVI
     LDPACGSGVF LVEAYKRLVL HWRWRNGWAR PDVDDLRPLL QRVHGVDLEE GAVELAAFSL
     CLSLCDALQP EEIRSSVKLF PRLADNTLHW SCFFEAKERG LVQAPVAVVV GNPPFESALT
     TDGARRSYAA YTKAHGALAD NQLAYLFLSE AMELLSPGGV LAMVEPAGFL YNQHALTFRQ
     SFFSRWSVRE VLDFVSVRGL FKKGEADPKV VVVIAEAVQP TADSRLLHAV FRRNGRATAE
     QGFDIDYYDL HWFGNAIAEK SRDIWRANLL GGSRVHDLIQ RLRDYPTLRD FAQKHQWDFG
     EGYIAGRKGI SRPAEHLVGK PLLPTSNLSR DGLDTRFLDV VPDKPIKDTK TARRFTPPLL
     LIKEHEDLHH GVWNGHYLAY KHEIVGLAAP AEQLGALSAI NDWLFREATV LRAYVAGISA
     RLFTQRATAI LSADVLAVPY PEDHDLDLSE NERIVAADVV EHQREFIRLG TGAAVMRPAP
     GEALAEFDDV FARQINAVYP RTALKALPGQ RWPGAICKAY VFGDGEVDWT GADGLRQKLD
     ALLQERRGTS LTITRITRLY DDGFVFLLKP DRHRFWTPAI ALRDADDVLA DLRAQGF
//