ID A0A239K9Y3_9ACTN Unreviewed; 3877 AA.
AC A0A239K9Y3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SNT14578.1};
DE Flags: Fragment;
GN ORFNames=SAMN06264365_1451 {ECO:0000313|EMBL:SNT14578.1};
OS Actinoplanes regularis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=52697 {ECO:0000313|EMBL:SNT14578.1, ECO:0000313|Proteomes:UP000198415};
RN [1] {ECO:0000313|EMBL:SNT14578.1, ECO:0000313|Proteomes:UP000198415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43151 {ECO:0000313|EMBL:SNT14578.1,
RC ECO:0000313|Proteomes:UP000198415};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FZNR01000045; SNT14578.1; -; Genomic_DNA.
DR OrthoDB; 5476914at2; -.
DR Proteomes; UP000198415; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19540; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198415}.
FT DOMAIN 203..278
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1240..1315
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2279..2354
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3308..3382
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:SNT14578.1"
SQ SEQUENCE 3877 AA; 412858 MW; A9297629B1653D73 CRC64;
TVITTAAPVM LPVSGAGPSM GRPIGNARVL VLDEFLQPVP VGVVGEVYIG GLGLAQGYVD
RPDLTAHRFV ADPSGVGGRL YRSGDLARWD GGGLLHFAGR SDEQVKIRGF RIEPAEVQAV
LQQYPQVAQA AVIARDNQLI GYLVAAGDLI DLAAVREFAA GRLPDYMIPL LVTLDRLPLT
INGKLDRAAL PAPDLASMVG DRGPETPLEE QLCRLFGEVL DLDRVGTEDS FLDLGGDSLL
AMRLVARIRV VLGAGLTVRE FFADPTVLGA AVQIMRGAGR TRAALTAKPR PETVPLSFAQ
RRMWFASQIE SSQHGDESPY NLPLHLHIRG DLDITALEAA LGDVADRHES LRTVYVENDG
VPEHRIVQGT AGHPGLPVTE VTEAGLEPAL AEEDGRRFDL GAGLPWRARL LVLGPDEFVL
AIVAHHIAVD GWSMGILSTD IRVAYAARRN GSVPDWADLP VRHSDYALWQ REILGDPADE
SSLIAGQLAY WRQKLAGVPL ELELPADRRR PMIASFRGGA IPLTLGADTH ARLLALGRDR
NATLFMVVHA ALAVLLSKMG AGEDIAIGTA VAGRDDVALE ELVGFFVNTL VLRTDLSGDP
SFAELLERVR ETDLAAYANQ EVPFDRLVEE LNPVRSMARH PLCQVMLTLR NMPPERWSLP
GLEIRSVEPT MTTSRMDLSL FLSERRDAAG AAAGLSGALV YAVDLFDEAT AQALADRLVR
ALEQVAGDPS VRVADLAVLG LAERERLLEV WNATSRPVPV GSLADLFAVQ VRLSPDAVAL
IGEQGDLTFR ELDVVSGRVA GVLRARGVGR GDLVAVMLPR SVEVPGVLLG VAKSGAGFVP
VDPQYPVDRI AFMFADAGPV LVVCTEATRD LVPSGVGFVL LEDLLAAPVE RVSVPVSVDD
VAYVIYTSGS TGRPKGVAVT HRGLGNLVAA QAERFAVSAG SRVLQLASWS FDASVSELCV
ALLSGAGLVV VPAGWLPPQR PLPEVCERFG VTHVTVPPSV LASVPELPSC VETLVVAGEV
CPPGLVQRWP GRRLINAYGP TETTVCATMS DPLTDGVPIG GPISNVRVYV LNDFLQPVPV
GVVGELYVSG PGVARGYVGR PGLTAQRFVA DPFGGGRLYR TGDRVKWAAS GELVFAGRAD
EQVKVRGFRI EPAEVQAVLE QYPQVVQAAV VARDSQLIGY LVAAGDLIDL AAVREFAAGR
LPDYMLPTLL TVLDTLPLNA NGKLDRAALP APDLPTTGRA AATAAEEILC GLFAEILGVE
SVPADVSFFE LGGDSLSAMR LIARIRRVFD AELSIGELFT APSAVEVAGL VSASAVVETR
IALMARERPQ LLPLSYGQQR MWFLNRIEDT GQGGVYNMPM ALRISGDLDV AALEAALGDV
AERHEILRTV YPENDGIAFQ QILRGEAARP PFSAVPISDG EPAAFVDRRF DLSTELPWRV
RLFVLAPGEF VLAIVAHHIA LDGWSIGVLR RDLRAAYTAR RQGQAPAWTD LGVQYADYAL
WQRDVLGHLD DESSLAAGQL RYWRKALAGV PQELTLLTDR PRPAVATFRG GSVPVRLDAQ
THADLLELGQ SRNATLFMVV HAAVAVLLTR MGAGSDISIG SVVAGRGDAV LEDLLGFFVN
TLVLRTDLSG NPTFAEVLDR VCETDLAAYA NQDVPFERLV EELNPARSLA LNPLFQIMCT
LENAAQSEMS LPGTHLEPVP LAEAAARVDL SFELSECRDE AGEPAGLTGR IRYAKDLFDE
STVLLLAERL TSVLRQVAVD ARVPLSRVDV TGDQRALVVE AWNDTARPVP ERSAVESIAA
RVAEVPDEIA VTGSAGSLTY RQLWQASTRV AGALAAHGVT RGQRIGLVME RSVDLLPILL
GVWRSGAAYV PVDPQWPLAR AEFVLRRTDL VVGDRDLPGI DVVAVETLLT GPDGPVVRPA
AADLAYVMYT SGSTGTPKGV EISHGSVAAL VQDSCWSAAA RGRVLLHAPH AFDASIYELW
VPLVSGGRVV VAEPSRMDAE TLAGLVRTHE LTAVHVTAGM FGVLADVSPD CFGGLGEVLT
GGDVVPVGAV SRVMAAEPGL RVTHLYGPTE ATLCATAHAI EPGAEVPGVL PIGGPRDNTR
VFVLDEFLMP APVGVLGELY ISGSGLARGY ADDAGLTAGR FVACPLGTGE RMYRTGDLAR
WDTAGRLYFA GRADEQVKIR GFRIEPAEIQ AVLTAHPRVS QAAVIAREDR PGDKRLVAYL
VADGDVLEVP AVREFAAQRL PEYALPTLIL LDVLPVTANG KLDRAALPAP DFGPPGGRAA
ETATEELLCG LFAEILGVPS VPVDVPFFEL GGDSLSAMRL IARIRAVFET DINVRGLFTH
PTVAGVAELV HGSEGAARPA LEARPRPDSL PLSYGQQRMW FLNRIEDAGQ SVAYNMPIVL
RISGDLDVAA LEAALGDVAD RHEVLRTIYP EVDGAAYQRI VEGAAGRPSL QVTQVAGSDV
TAELTAYLEQ GFDLGVELPW RARLLVTEAG EFVLAIVAHH IALDGWSMGV LTRDLRAAYT
ARRQGQVPAW SSLDVQYADY ALWQREVLGD LDDESSLIAE QLAFWRETLS GAPQELVLPT
DRPRPAVASM RGATVNVRAG AETHARLVEL AQRSGSTVFM VAHAALAVLL SRMGAGIDIP
LGTSVAGRGD AALNDLVGFF INTLVLRTDL SGDPTFTELL ARVRETDLAA YANQEVPFER
LVDELSPVRS LARNPLFQVM FVVQNLPQNQ DGWSLPGVLV RPEDHDPVHA AAKFDFSVIL
VEHHDEHGRP AGFTTEILYA TDLFDESTAQ SLADRLVAVL TQVAADPQLT LSQVDVLTSV
ERALVTREWN DTAVPVSAVS VPELIARWVG ETPDAVAVRD GGGRSLTYGQ LDEWSQGVAS
GLRSAGVNRG NRVGLCLPRG VEMVAAMLGA WRVGAAFVPL DPQLPVARRE LMAAGTSLVL
SVWDPVWETG AGIAPVALDG RDLAYVIYTS GSTGTPKGVA VAHAGVASLA QVMAPILDVS
AGTAALQFAS FSFDASVLDV VTVLGAGGTL VIADDEQRQD MAALSRLVRD ADVRVASVVP
SLLAALDPAQ VAGIRRWVLG AEFLSAGLAS RWSAGSQVWN SYGPTEATVI TTAAPVTLPV
AGAGPSMGRP IGNARVLVLD EFLQPVPVGV VGEVYIGGLG LARGYVNRPD LTAHRFVADP
SGVGGRLYRS GDLARWDREG LLHFAGRSDE QVKIRGFRIE PAEVQAVLQQ HPQVAQAAVI
ARDNQLIGYL VAAGNELDVA AVREFAAGRL PEYMLPTLLV LDALPLNANG KLDRAALPAP
DLPTTGRAAA TATEQILCEL FAEILGVESV PADASFFELG GDSIMSMLLV SRARRAGLTI
TARNIFEHRT PAALATVATT EDHATTGEPG TGDIPLTPVM HELLHRAGDH LGQVYQSTVV
VTPAGLDLGT LTASLQALVD HHDMLRATLH TDRLTVPEPG TVDVEQWIRR VDATTGPPAD
LLPEQTAEAV ARLDPRGGVM AQFVWFDCAP GVPGRLLLVL HHLVMDGVSL RVLLSDLAAW
HEALAGGERA ELETVPASFR HWARSLAAQA GSADRRAELA RWTSVVSDTN PVTALAPGAA
HGPVHEVTTT LPADVTSTIL TAVPANFHAD VDDVLLATLV VALSAWCRRQ GQPDARDYLI
DLESHGRVPL TASMDLSRTV GWFTEQHPVR LSARAGEFAD VRAGRGAAGR ILKRAKEELR
AIPGDGLGYG ILRHLDPETA PVLAGLPAAR IGFNYLGRFA EAADGGQAWN RASEGDGYTD
TSGAIPAAHA LEVLALVRDR PAGSELTLVL AAPRLVVTEA ALRSLADDWA AALGGLARHV
SRPGSGGHTP SDFSLIKLNQ RQIDELEGAF SDEGVNQ
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