ID A0A239KEW2_9ACTN Unreviewed; 1101 AA.
AC A0A239KEW2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05421812_103505 {ECO:0000313|EMBL:SNT16897.1};
OS Asanoa hainanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Asanoa.
OX NCBI_TaxID=560556 {ECO:0000313|EMBL:SNT16897.1, ECO:0000313|Proteomes:UP000198362};
RN [1] {ECO:0000313|EMBL:SNT16897.1, ECO:0000313|Proteomes:UP000198362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.5593 {ECO:0000313|EMBL:SNT16897.1,
RC ECO:0000313|Proteomes:UP000198362};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FZPH01000003; SNT16897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239KEW2; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000198362; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198362}.
FT DOMAIN 36..359
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 360..686
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 821..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 57..64
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1101 AA; 119007 MW; 8C340044F6A663A8 CRC64;
MTQPSLFTTA PAPRKAASAG PRYTPVELAR LLGMRYAPTA EQSAIIAAPV EPLLVVAGAG
SGKTETMAAR VVWLVANGYA TPDQILGLTF TRKAAGELAH RVRMRLGQLV RRLGRAGDLS
GEATISTYHS YAARVVTEHG LRSGYEPATR LLTEASRWQI VDLIVRNYDG DMSDVERAAS
TVTDAVLALS GELAEHLVTP DELAGWTGRF FAEVQGRPGR VYADVKKALA TQQARLALLP
MVRAYDKRKI DFEAMDFGDQ MARAARVARD HADVGAVERA RYPIVLLDEF QDTSHAQVVL
LRSLFGGGHP VTAVGDPCQS IYGWRGASAG TLERFPNEFA RADGKPARSL TLTTSWRNRP
EILRVANQLS APLRAAGAQV AELAPAYSVD EPIRGRETVH CALLPTVGDE AAWIADSVLA
AWWGAARMAD ALPEHIPLER RPTTAVLVRV RSQIPAIENA LRSRGLPVEV VGLGGLLDTP
EVRDVVCTLR VLADPTDGAS LLRLLTGARW RIGPRDLVAL HRRSRSIAAA RRDLAQPDEE
DLVPDALDEA TLVEALADLG PAQLYSAEGF ARLRAYGNEL ALLRYRIDQP LPDLIADVER
TIGLDVEVAV RAGTGGRGGD AGLARGHLDA LGDVAARFAR DSDGGALPGF LAYLTAAEDE
ERGLEPGEVE VVEGAVQVLT AHAAKGLEWD VVAVAGLTRG GWPGTARASD HYLQGLGVLP
FPLRGDAGGL PRFPLDDTGD QREVMTALSE FNEEWKAHDE REERRLAYVA VTRPRRLLLC
SGYWWGEGVK RPRGPSRFLV EVHDACLAGS GVVDEWAPEP AGEANPMVDE TPSAEWPGDP
LGPRRPTMTE AATLVRRLMT DPDADALLDP AAADDAARWR REVDLLIAER DQLVRGPGPL
EVVLPDHLTV SQLVLLQRDP QALARSLRRP MPSRPDPYAR RGTAFHTWLE QRFGAVRLLD
VDELPGAADE DAAPDEALAE LQELFLASDW ADRTPIEVEV PFATAVGGVV LRGRMDAVFA
DPGGRYDVVD WKTGRRPTGA DERAAAIQLA AYRLAWAHLA GVPVDRVRAA FHYVRAGETI
RPADLLDADG LAALVTALPT V
//
