ID A0A239KPI6_9SPHN Unreviewed; 615 AA.
AC A0A239KPI6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=SAMN06295955_11584 {ECO:0000313|EMBL:SNT19940.1};
OS Sphingopyxis indica.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingopyxis.
OX NCBI_TaxID=436663 {ECO:0000313|EMBL:SNT19940.1, ECO:0000313|Proteomes:UP000198339};
RN [1] {ECO:0000313|EMBL:SNT19940.1, ECO:0000313|Proteomes:UP000198339}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS15 {ECO:0000313|EMBL:SNT19940.1,
RC ECO:0000313|Proteomes:UP000198339};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; FZPA01000015; SNT19940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239KPI6; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000198339; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF50; DNA (CYTOSINE-5)-METHYLTRANSFERASE CMT3; 1.
DR Pfam; PF00145; DNA_methylase; 2.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000198339};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 615 AA; 66882 MW; 35767423C850821B CRC64;
MKLPGLFIDG FAGGGGASTG IAQAIGRDPD IAVNHSSAAI AIHKANHPGT EHHCCDIRLP
FLPRTATRGR KVWGVWFSPD CKEYSKAKGG PVKDRSIRAL CWEVIEWVRE TQPEVGFLEN
VEEFQYAAPL DGEGVPIADQ KGREFKRFVR ALRGLGFRVQ WRILKACDYG APTNRKRLYM
IYRRDGLPIV WPKPTHAPAN DNRVLRGEML PYRTAAECID WTIPCPSIFE RDRELAEATK
RRIAHGVMRY VVNAARPFIV PLTHQGSVRV HDLEDPFRTI TGAHRGELAL SDVELAPHLM
TNRNAQKPFN GADEPTHTIT AGGAHLNLVG ATLVGVGGRR GQSAPMAVDG PYPTTTVKAD
TAIACCTMVK MGNGEREGQA PRALDVAKPY GTVTAKGSQA AAVTAFLSSF YGSDKTNGSG
DPERPLRSAR AGGQHHAVVA AHIEQANTGM VGHTPRKPLS TIVGKGCTQR IVETTMIERD
ALPPDLMERA VRVAAFLIKY YGNESDGHGL NQPIGTVTTK DRFAVVTVTI DAKTYVIVDI
GLRMLKPREL ARAQGFPDDY VLDPVVRKLV RGKWVEKPLT IAEQISAIGN SVCPPVARAL
VAANQPGIAE ERLAA
//
