ID A0A239LKU2_9ACTN Unreviewed; 364 AA.
AC A0A239LKU2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:SNT30433.1};
GN ORFNames=SAMN05216252_12038 {ECO:0000313|EMBL:SNT30433.1};
OS Actinacidiphila glaucinigra.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Actinacidiphila.
OX NCBI_TaxID=235986 {ECO:0000313|EMBL:SNT30433.1, ECO:0000313|Proteomes:UP000198280};
RN [1] {ECO:0000313|EMBL:SNT30433.1, ECO:0000313|Proteomes:UP000198280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.1858 {ECO:0000313|EMBL:SNT30433.1,
RC ECO:0000313|Proteomes:UP000198280};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; FZOF01000020; SNT30433.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239LKU2; -.
DR OrthoDB; 9775207at2; -.
DR Proteomes; UP000198280; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30566:SF25; INNER MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR30566; YNAI-RELATED MECHANOSENSITIVE ION CHANNEL; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000198280};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 126..167
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 168..235
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 245..330
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 39061 MW; 10272D5C3B32FA7D CRC64;
MNRALTLHDL IVAGAAIAAG ALAGLLLRLA LKWLSERARS TRWGGDDIVV AALRTVVPWA
ALAAGAWVGA AALPLTRVVD RTVAQVLVAV LILATTIAAG RMVAETVRSL ALSRSGVAAS
ATIFVNISRV AVMAVGFLVL LQTLGISVTP LITALGVGGL AVALALQDTL ANLFAGVHIL
ASKTVQPGDY IRLSSGEEGY VVDINWRNTV VRQLSDNLVI IPNAKLASAI ATNFHQPEQQ
MSLIVQAGVG YGNDLEHVER VTIEVAGQVM AHVEGGIPEH DSVVRFHTFG ESRIDFSVIL
RTSEYGEQYR IKHEFIKRLH RRYQEEGIEI SFPTRNVVLR QEQPDGITLP HQRTVPAPDR
TPGA
//
