ID   A0A239LSA9_9ACTN        Unreviewed;       397 AA.
AC   A0A239LSA9;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Acetyl-CoA acyltransferase {ECO:0000313|EMBL:SNT32524.1};
GN   ORFNames=SAMN05421812_104497 {ECO:0000313|EMBL:SNT32524.1};
OS   Asanoa hainanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Asanoa.
OX   NCBI_TaxID=560556 {ECO:0000313|EMBL:SNT32524.1, ECO:0000313|Proteomes:UP000198362};
RN   [1] {ECO:0000313|EMBL:SNT32524.1, ECO:0000313|Proteomes:UP000198362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.5593 {ECO:0000313|EMBL:SNT32524.1,
RC   ECO:0000313|Proteomes:UP000198362};
RA   Kim H.J., Triplett B.A.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; FZPH01000004; SNT32524.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A239LSA9; -.
DR   OrthoDB; 5167532at2; -.
DR   Proteomes; UP000198362; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:SNT32524.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198362};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SNT32524.1}.
FT   DOMAIN          8..258
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          268..389
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        94
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        346
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        377
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   397 AA;  41716 MW;  EAE5EC9C58C36355 CRC64;
     MPRSVRDVAF VDGVRTPFGK AGGMYAHTRA DDLVIRCIRE LLRRNPQLPP AAVEEVAIAA
     TTQIGDQGLT IGRTAALLAG LPKTVPGFAI DRMCAGAMTA VTNVAGGIAM GAYDVAIAGG
     VEHMGRHPMG EGVDPNPRIL AEKLVDPSAL VMGKTAENLH DRLPAVTRER ADAFGLASQV
     KTAKAYANGK LQDDLVPVAL RDPENGWGLA TVDEAPRDTS MEKLATLKTP FRPHGRVTAG
     NSAGLNDGAT ASIIAAEDTA RELGLPVAMR LVSYGFVGVE PEVMGVGPIP ATEKALRIAG
     LDIADIGLFE LNEAFAVQVL AFLDHFGVAD DDPRVNPWGG AIAVGHPLAS SGVRLMTQLA
     RQFAEHPEVR YGITAMCIGI GMGGSVIWEN PNWEGTK
//