ID   A0A239NF78_9ACTN        Unreviewed;       681 AA.
AC   A0A239NF78;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase {ECO:0000313|EMBL:SNT53525.1};
GN   ORFNames=SAMN05443665_104041 {ECO:0000313|EMBL:SNT53525.1};
OS   Actinomadura meyerae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=240840 {ECO:0000313|EMBL:SNT53525.1, ECO:0000313|Proteomes:UP000198318};
RN   [1] {ECO:0000313|EMBL:SNT53525.1, ECO:0000313|Proteomes:UP000198318}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44715 {ECO:0000313|EMBL:SNT53525.1,
RC   ECO:0000313|Proteomes:UP000198318};
RA   Kim H.J., Triplett B.A.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC       synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
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DR   EMBL; FZOR01000040; SNT53525.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A239NF78; -.
DR   Proteomes; UP000198318; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I-like.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR017926; GATASE.
DR   InterPro; IPR006221; TrpG/PapA_dom.
DR   NCBIfam; TIGR00566; trpG_papA; 1.
DR   PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR   PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   Pfam; PF00117; GATase; 1.
DR   PRINTS; PR00097; ANTSNTHASEII.
DR   PRINTS; PR00099; CPSGATASE.
DR   PRINTS; PR00096; GATASE.
DR   SUPFAM; SSF56322; ADC synthase; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605,
KW   ECO:0000313|EMBL:SNT53525.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198318};
KW   Transferase {ECO:0000313|EMBL:SNT53525.1}.
FT   DOMAIN          164..408
FT                   /note="Chorismate-utilising enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00425"
FT   DOMAIN          488..674
FT                   /note="Glutamine amidotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00117"
FT   REGION          424..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        568
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        657
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        659
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ   SEQUENCE   681 AA;  71885 MW;  CCFFB41DE0D0BFFC CRC64;
     MPGEALMESA AEVFRVHLDL DLEPVDVLRR FRDRDRLVGL LGDWHHGEAV IAFDPVRVAE
     DPFAAVDVPR REKPAAGFGG GWIGVWGYRM AHVLERVPEP HARPVPQPDH RVGFYDRVLR
     RVDGEWWLES LGPTDPADVL AALARAAEPR TFGVGEFALT PDPASHRAAV RRALDHIAAG
     DIFQVNLCAR LEARFDGDPL ELFCRGYRTL KPAYAAYVAA PEGAVASFSP ELFLRRTGGT
     VITSPIKGTA PLGTDPRELL DSGKDRAENI MIVDLMRNDL SRVCAPGSVR VPALVRPERH
     AVWHLVSDVT GRLADGATDA GLLRATFPPG SVTGAPKPRA MEIAARLEAT GREAYTGAIG
     HVGPAAGVEL NVAIRTFEIA GGRVWLGVGG GIVAESTPEG EYAELLTKAA PLIRAIGGTL
     DHLSPAAGAG RPSAGSTGTA SSGTASSGTA PSGTAPMSTS PSGPVPTVRC RRPAAAPARR
     AAAPARVLFI DNYDSFVYNL VHDARDLGAA TEVIRNDETG VDDLVRAARD GDFTHLVISP
     GPGAPAEAGI SVEAARVLGP SVPVLGVCLG HQAIAEAYGA RVVRARRIVH GKPSLLHHAG
     RGLFRGLPSP VSCARYHSLV VTDDGLPGEL EVTARTASGT IMGLRHREHP THGLQIHPES
     ILTPHGRGML RNFLAIGTAA G
//