ID A0A239NHK6_9ACTN Unreviewed; 476 AA.
AC A0A239NHK6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=GntR family transcriptional regulator / MocR family aminotransferase {ECO:0000313|EMBL:SNT53609.1};
GN ORFNames=SAMN05443665_104052 {ECO:0000313|EMBL:SNT53609.1};
OS Actinomadura meyerae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=240840 {ECO:0000313|EMBL:SNT53609.1, ECO:0000313|Proteomes:UP000198318};
RN [1] {ECO:0000313|EMBL:SNT53609.1, ECO:0000313|Proteomes:UP000198318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44715 {ECO:0000313|EMBL:SNT53609.1,
RC ECO:0000313|Proteomes:UP000198318};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; FZOR01000040; SNT53609.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239NHK6; -.
DR OrthoDB; 5415143at2; -.
DR Proteomes; UP000198318; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:SNT53609.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000198318};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:SNT53609.1}.
FT DOMAIN 24..92
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 84..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 51254 MW; 7D06DF1D5ED1E744 CRC64;
MAESWVNPAE RLGSDLHLDL SGPGSRRAVL SNALREAVRD GRLAPGTRLP PYRSLAADLG
LARNTVAGAY AELVAEGWLI AQQGSGTRVA PRTEPVRSPR VPKRTPARPA PPAHDLRQGQ
PDASAFPRSA WLSAARRALN AAPNEAFGPG DPRGRPELRR ALTEYLARAR GVRTAPDRIV
VCSGFAHALR LLFGGRVLRG PLAAESYGLA FHRSILAAAS VRTVPLTLDA HGARTAELAD
LKGVRAALLT PAHQFPTGGP LHPERRVTAL DWARTCGGVI LEDDYDGEFR YDREPVGAVQ
GLDPERVVYI GSVSKSLSPA VRLGWMVLPE HLVPAVLAAK GEREAWAGVT DQLTLADLID
SGHYDRHVRR MRQRYRARRD RLVAALDARA PHIAPTGIAA GLHAVLSLPP RTERSTVKAA
TWHSVALDGL ADFRHPNATM PARDGLVVGY ATPPDHGYAQ AIEALCRILP PDPAEH
//
