ID A0A239QWI6_9MICO Unreviewed; 872 AA.
AC A0A239QWI6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN06298212_1299 {ECO:0000313|EMBL:SNU02230.1};
OS Ruaniaceae bacterium KH17.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Ruaniaceae.
OX NCBI_TaxID=1945888 {ECO:0000313|EMBL:SNU02230.1, ECO:0000313|Proteomes:UP000214750};
RN [1] {ECO:0000313|EMBL:SNU02230.1, ECO:0000313|Proteomes:UP000214750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH17 {ECO:0000313|EMBL:SNU02230.1,
RC ECO:0000313|Proteomes:UP000214750};
RA Sun Z.S., Albrecht U., Echele G., Lee C.C.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FZQV01000029; SNU02230.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239QWI6; -.
DR OrthoDB; 4280289at2; -.
DR Proteomes; UP000214750; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SNU02230.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000214750};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNU02230.1}.
FT DOMAIN 466..552
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 872 AA; 96300 MW; A62D1EE103C5A53B CRC64;
METAPLKSFA TSARTELIRE VSARITAVLA QGSLERVEQP SAVAALERAI AATGGGDKGK
SHVADKVAYT WFNRIVALRF MDANGYTGIG VVSPGAGQIG QPEVLATAKR GQIDLEVVKR
SNSMTITGLL SETRPPRPGV DAQTEAYSLL LADYCRFWNK TMPFMFEREG DYTELLIPGN
LLAEDSVLSR SVQVLSTDVC EDVEVIGWLY QFYISERKDE VFAGFKKNRK AGADEIPAAT
QLFTPHWIVR YLVENSVGRL WMLNHPESCL VDQMDYYIAP VDEETDFLKI SSPEELTVID
PACGSGHMLT YAFDLLYAIY EEEGYTPSQI PGLILNNNLF GAEIDPRAGA LAAFALAMKA
TAKRKLFLKQ PVESNVCVIE PLSFRSDEID VLTAEQGGDL ASQGFWNQFE NADTLGSLIR
PDVSQIVFAK GSLERIDAEN DIIYSGTVER ARKLIRQAEI LSNVYAVVVA NPPYMGSKQM
NVLLSQFMKD EYPNSKSDLF AGFIERCTNL AGLRGAVAMI TMQSWMFLSS YEKLRASLLT
KQRITSMLHL GARAFDSIGG EVVSSAAFVL ANVPSGARSS ANMYPGTFIR LVDGTSEAEK
VAALGTALES TAKDSGFHLA SDADFTAIPG SPIVYWLSEK MRSSFSIGKP LSEVARLRQG
LATADNNRFL RQWWEVAATR TKFSCTSREE AATSRARWFP YNKGGEFRKW YGNQEHVVNW
ENDGNEIRTF GIESGGRPRS RAQNTDTYFS PSVSWSDISS GEAAFRRYPP GFIHDSTGHS
GFGDPTMLDQ ISLLLNSKFV MEIMKVVAPT LHFHIGYVGL VPVAEEIGEL STDTVGRLIE
TAKDDWDCFE TSWSFERNPL VDQRSLEGGN FD
//
