ID   A0A239SMR5_9STRE        Unreviewed;       746 AA.
AC   A0A239SMR5;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=ATP dependent protease {ECO:0000313|EMBL:SNU86054.1};
GN   Name=clpE {ECO:0000313|EMBL:SNU86054.1};
GN   ORFNames=SAMEA4412692_00059 {ECO:0000313|EMBL:SNU86054.1};
OS   Streptococcus merionis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=400065 {ECO:0000313|EMBL:SNU86054.1, ECO:0000313|Proteomes:UP000215185};
RN   [1] {ECO:0000313|EMBL:SNU86054.1, ECO:0000313|Proteomes:UP000215185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13788 {ECO:0000313|EMBL:SNU86054.1,
RC   ECO:0000313|Proteomes:UP000215185};
RG   Pathogen Informatics;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; LT906439; SNU86054.1; -; Genomic_DNA.
DR   RefSeq; WP_026216877.1; NZ_LT906439.1.
DR   AlphaFoldDB; A0A239SMR5; -.
DR   STRING; 1123308.GCA_000380085_00390; -.
DR   KEGG; smen:SAMEA4412692_0059; -.
DR   eggNOG; COG0542; Bacteria.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000215185; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Hydrolase {ECO:0000313|EMBL:SNU86054.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:SNU86054.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215185}.
FT   DOMAIN          356..391
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   REGION          59..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   746 AA;  83515 MW;  79D7633187E9E06C CRC64;
     MLCHNCKMND ATIHLYSNYN GRQQQVDLCQ NCYQIMKTDP ENPILRGLSQ IQNQQRSPFD
     DFFDNLSNFQ HPSQAPGNQI PPTQAGRNNS NRGGNQQPPK KGLLDEFGIN VTEIARRGGI
     DPVIGRDEEI VRVIEILNRR TKNNPVLIGE PGVGKTAVVE GLAQKIVDAD VPHKLQNKQV
     IRLDVVSLVQ GTGIRGQFEE RMQKLMEEIR ERQDVILFID EIHEIVGAGS AGDGNMDAGN
     ILKPALARGE LQLVGATTLN EYRIIEKDAA LERRMQPVRV DEPSVEETIT ILKGIQKRYE
     DYHHVRYTDE AIEAAANLSN RYIQDRFLPD KAIDLLDESG SKMNLTLNFV DPKEIDQRLV
     EAENLKAQAT RDEDYEKAAY FRDQIAKYKE MQKATLDEKD IPVITEKEIE AIVERKTNIP
     VGDLKEKEQS QLVNLASDLK AHVIGQDEAV DKIAKAIRRN RVGLGAPNRP IGSFLFVGPT
     GVGKTELSKQ LAIELFGSAD SMIRFDMSEY MEKHSTAKLV GAPPGYVGYD EAGQLTEKVR
     RNPYSLILLD EIEKAHPDVM HMFLQVLDDG RLTDGQGRTV SFKDTIIIMT SNAGTGKVEA
     SVGFGAAREN RTNSVLGQLG DFFSPEFMNR FDGIIEFQAL SKDNLLQIVD LMLNNVNDRL
     ANNGISLHVT DKVKEKLVDL GYDPKMGARP LRRTIQDHIE DAITDFYLEN PTEKDLRAVM
     TSSGNIAIKP AKKTEKTNTT DEETDQ
//