ID A0A239SMU1_9STRE Unreviewed; 484 AA.
AC A0A239SMU1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN Name=cysG {ECO:0000313|EMBL:SNU86751.1};
GN ORFNames=SAMEA4412692_00363 {ECO:0000313|EMBL:SNU86751.1};
OS Streptococcus merionis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=400065 {ECO:0000313|EMBL:SNU86751.1, ECO:0000313|Proteomes:UP000215185};
RN [1] {ECO:0000313|EMBL:SNU86751.1, ECO:0000313|Proteomes:UP000215185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13788 {ECO:0000313|EMBL:SNU86751.1,
RC ECO:0000313|Proteomes:UP000215185};
RG Pathogen Informatics;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
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DR EMBL; LT906439; SNU86751.1; -; Genomic_DNA.
DR RefSeq; WP_018373850.1; NZ_LT906439.1.
DR AlphaFoldDB; A0A239SMU1; -.
DR STRING; 1123308.GCA_000380085_01299; -.
DR KEGG; smen:SAMEA4412692_0363; -.
DR eggNOG; COG0007; Bacteria.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000215185; Chromosome 1.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000215185};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 5..214
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 266..470
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 484 AA; 53247 MW; 68792328A7779393 CRC64;
MTGFVTLLGA GPGDVDLLTV KGVRRLQEAD VLVFDRLVNP SLLRYVKADC EIIDVGKQPG
MPCVRQEEIE NILITKAKEG KRVVRLKSGD PYIFGRGGEE ASTLVKAGVA FEVVPGITSA
IAGLAYAGIP MTYRDIATSF HVFTGHLKDE TEALNWEAIS QLKGTLVFLM GMKHLETIVH
ELRTRGFDKE TPVAIIEWGT HPQQRSIDGN LETIVSLVAE HAFKAPSLIV VGDVVAFRKE
LNFYEHLPLF AKKIVIQESP TGKLPTLLKD DGANLVTFPA RNKVEKLTCD LPDLSTVDGL
LIADTQSWGL LLELLRQEKI DLRTLAHIRF AAIGQHTIKE IERSGILLEH KGATMTDAAL
LAAMSEEKGN WYSIAPRHKA EELARLYPFP VLKTHSLGFE DTLEKIDWAE IEAVCLPNSV
AAMNFVAFAK ETGVTSLDIP IVVMGESTSE VLKQAGFTSL IMTDDLTIAS IRDKCREILK
RSAK
//
