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Database: UniProt
Entry: A0A239SP18_9STRE
LinkDB: A0A239SP18_9STRE
Original site: A0A239SP18_9STRE 
ID   A0A239SP18_9STRE        Unreviewed;       343 AA.
AC   A0A239SP18;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroG {ECO:0000313|EMBL:SNU86484.1};
GN   ORFNames=SAMEA4412692_00249 {ECO:0000313|EMBL:SNU86484.1};
OS   Streptococcus merionis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=400065 {ECO:0000313|EMBL:SNU86484.1, ECO:0000313|Proteomes:UP000215185};
RN   [1] {ECO:0000313|EMBL:SNU86484.1, ECO:0000313|Proteomes:UP000215185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13788 {ECO:0000313|EMBL:SNU86484.1,
RC   ECO:0000313|Proteomes:UP000215185};
RG   Pathogen Informatics;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; LT906439; SNU86484.1; -; Genomic_DNA.
DR   RefSeq; WP_018373146.1; NZ_LT906439.1.
DR   STRING; 1123308.KB904539_gene768; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000215185; Chromosome 1.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000215185};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215185};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:SNU86484.1}.
FT   DOMAIN       37    333       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   343 AA;  38813 MW;  13C5A8A53BCD224E CRC64;
     MTFKAISQRI DIDKVRAISK LTGECLEKKK ARDRELEAII QGEDDRLLLV IGPCSSDNEA
     AVLEYANRLA QLQEQVKDRI FMVMRVYTAK PRTNGDGYKG MMHQPKADAA PSLINGIRAV
     RNLHYRVITE TGLTTADEML YPENLSLVED LVSYVAIGAR SVENQQHRFV ASGIDVPTGL
     KNPTSGNLNV MFNGVYAAQH KQSFLFNGQE VETEGNPLAH VILRGAINEF GKIQPNYYYD
     NLLETIAQYE KMGLTNPFII VDTNHDNSGK NYLEQIRIIR QTLINRAWNP KINQVVRGFM
     IESYLEDGRQ DEPNVFGQSI TDPCLGWDKT KELIQEIYRT LGE
//
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