ID   A0A239SRC4_9STRE        Unreviewed;       448 AA.
AC   A0A239SRC4;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN   Name=mepA {ECO:0000313|EMBL:SNU87294.1};
GN   ORFNames=SAMEA4412692_00593 {ECO:0000313|EMBL:SNU87294.1};
OS   Streptococcus merionis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=400065 {ECO:0000313|EMBL:SNU87294.1, ECO:0000313|Proteomes:UP000215185};
RN   [1] {ECO:0000313|EMBL:SNU87294.1, ECO:0000313|Proteomes:UP000215185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13788 {ECO:0000313|EMBL:SNU87294.1,
RC   ECO:0000313|Proteomes:UP000215185};
RG   Pathogen Informatics;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR   EMBL; LT906439; SNU87294.1; -; Genomic_DNA.
DR   RefSeq; WP_018374580.1; NZ_LT906439.1.
DR   AlphaFoldDB; A0A239SRC4; -.
DR   STRING; 1123308.GCA_000380085_02035; -.
DR   KEGG; smen:SAMEA4412692_0593; -.
DR   eggNOG; COG0534; Bacteria.
DR   OrthoDB; 9776324at2; -.
DR   Proteomes; UP000215185; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13138; MATE_yoeA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215185};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        50..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        420..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   448 AA;  48564 MW;  287F37CF07FA0C75 CRC64;
     MHDLTKGSPI KVILLFTIPL VVGSIFQLLY NFADSMIVGH TLGEQSFAAV GATGSITFLI
     LGFAQGLTGG FSVILAQRFG AKDTVGIKRS YATGLVLSIG VGLVLTVLSL AFLRTFLTIM
     QTPEELIEQS HRFLKAIFGG MIATILYNYL SNSIRALGDS RTPLLALIVA VILNVILDFV
     FILTFKMGVF GAGVATILAQ MVSVFFLFWH IKRRVPQLQL SKNDWQLLTK KESKRHLQLG
     LPMGFQASII AIGAMTLQYA LNQLGTEAIA AQAIASRTDQ LAMSPMVNLG QAISTFTAQN
     YGAKAYRRIF EGVKKTVALS VAWSVFFAVI LLLGNRTFST LFLPEGSEGI YKMAFSYYLI
     NGLCYWILAI LFVLRGFIQG LGKSFAPTLA GVMELVMRAA VALIGLHYFG FAGVAAANPA
     AWIGSVMVLI PTTYIVVKQI KVAMVQGV
//