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Database: UniProt
Entry: A0A239TA81_9FIRM
LinkDB: A0A239TA81_9FIRM
Original site: A0A239TA81_9FIRM 
ID   A0A239TA81_9FIRM        Unreviewed;       210 AA.
AC   A0A239TA81;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE            EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN   Name=cysG_2 {ECO:0000313|EMBL:SNU93763.1};
GN   ORFNames=SAMEA4364220_00075 {ECO:0000313|EMBL:SNU93763.1};
OS   Megamonas hypermegale.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC   Megamonas.
OX   NCBI_TaxID=158847 {ECO:0000313|EMBL:SNU93763.1, ECO:0000313|Proteomes:UP000215383};
RN   [1] {ECO:0000313|EMBL:SNU93763.1, ECO:0000313|Proteomes:UP000215383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10570 {ECO:0000313|EMBL:SNU93763.1,
RC   ECO:0000313|Proteomes:UP000215383};
RG   Pathogen Informatics;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC         Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00001156};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005010}.
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DR   EMBL; LT906446; SNU93763.1; -; Genomic_DNA.
DR   RefSeq; WP_027890397.1; NZ_NFIW01000022.1.
DR   AlphaFoldDB; A0A239TA81; -.
DR   GeneID; 78506122; -.
DR   eggNOG; COG1648; Bacteria.
DR   OrthoDB; 9773765at2; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000215383; Chromosome 1.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 1.10.8.610; SirC, precorrin-2 dehydrogenase, C-terminal helical domain-like; 1.
DR   InterPro; IPR028161; Met8.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR042518; SirC_C.
DR   InterPro; IPR019478; Sirohaem_synthase_dimer_dom.
DR   InterPro; IPR006367; Sirohaem_synthase_N.
DR   NCBIfam; TIGR01470; cysG_Nterm; 1.
DR   PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   Pfam; PF10414; CysG_dimeriser; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215383}.
FT   DOMAIN          149..204
FT                   /note="Sirohaem synthase dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF10414"
SQ   SEQUENCE   210 AA;  23812 MW;  8F6F31EDC3A43624 CRC64;
     MYPINLILDD KPCVVIGGGH VALRKVKALL EAKAKVTVIS PILVNELKVM AQNNQIIWLQ
     KYYETGDLNG FELVICAVGE DNASQQIYTD AHKARILINV VDKLPLCDFA LPAKIRRGNL
     LITFSTNGKS PALSRYLRCK MEKEFDDTYA LWLDRLSILR NEAIAKLPTS DDREIFWRSA
     LSDEVMELVK QKKYDEAEGI IRDAIDSFRP
//
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