ID A0A239TAK6_9FIRM Unreviewed; 250 AA.
AC A0A239TAK6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN ORFNames=SAMEA4364220_00144 {ECO:0000313|EMBL:SNU94108.1};
OS Megamonas hypermegale.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Megamonas.
OX NCBI_TaxID=158847 {ECO:0000313|EMBL:SNU94108.1, ECO:0000313|Proteomes:UP000215383};
RN [1] {ECO:0000313|EMBL:SNU94108.1, ECO:0000313|Proteomes:UP000215383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10570 {ECO:0000313|EMBL:SNU94108.1,
RC ECO:0000313|Proteomes:UP000215383};
RG Pathogen Informatics;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU003862};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|RuleBase:RU003862}.
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DR EMBL; LT906446; SNU94108.1; -; Genomic_DNA.
DR RefSeq; WP_027889923.1; NZ_NFIW01000008.1.
DR AlphaFoldDB; A0A239TAK6; -.
DR GeneID; 78506188; -.
DR eggNOG; COG0685; Bacteria.
DR OrthoDB; 9803687at2; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000215383; Chromosome 1.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003862};
KW Methyltransferase {ECO:0000313|EMBL:SNU94108.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003862};
KW Reference proteome {ECO:0000313|Proteomes:UP000215383};
KW Transferase {ECO:0000313|EMBL:SNU94108.1}.
SQ SEQUENCE 250 AA; 29064 MW; 70468E561620EDAE CRC64;
MTKIAVELVP RDLAIFEEEL KAIKADIPDV DFINIPDLLS CDIRSWDGAG IAKKYFKDAV
PHLRAMDFDF TCELPIKDKL KKYDIKEVLV IEGDPPQTMT HQVYPTISTD IIKKFSDEMP
DIKVYAGIDQ YRSSIKEEEY RIRRKMLAGA KGFFTQPFFD MRYLEIYADI LDGMDIYWGV
SPVLSQRSVS YWRNKNNVIF PKDFEPTLEW NVAFARKVVE FAKAHNQNVY LMPIKAKIMP
YLEGVLKNNI
//
