ID A0A239U541_9FIRM Unreviewed; 235 AA.
AC A0A239U541;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Cobalt-precorrin-2 C(20)-methyltransferase {ECO:0000313|EMBL:SNV04538.1};
DE EC=2.1.1.151 {ECO:0000313|EMBL:SNV04538.1};
GN Name=cbiL {ECO:0000313|EMBL:SNV04538.1};
GN ORFNames=SAMEA4364220_02000 {ECO:0000313|EMBL:SNV04538.1};
OS Megamonas hypermegale.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Megamonas.
OX NCBI_TaxID=158847 {ECO:0000313|EMBL:SNV04538.1, ECO:0000313|Proteomes:UP000215383};
RN [1] {ECO:0000313|EMBL:SNV04538.1, ECO:0000313|Proteomes:UP000215383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10570 {ECO:0000313|EMBL:SNV04538.1,
RC ECO:0000313|Proteomes:UP000215383};
RG Pathogen Informatics;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|PIRNR:PIRNR036427}.
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DR EMBL; LT906446; SNV04538.1; -; Genomic_DNA.
DR RefSeq; WP_027889151.1; NZ_LT906446.1.
DR AlphaFoldDB; A0A239U541; -.
DR GeneID; 78507985; -.
DR eggNOG; COG2243; Bacteria.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000215383; Chromosome 1.
DR GO; GO:0043781; F:cobalt-factor II C20-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11645; Precorrin_2_C20_MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012382; CobI/CbiL.
DR InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR NCBIfam; TIGR01467; cobI_cbiL; 1.
DR PANTHER; PTHR43467; COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR43467:SF2; COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036427; Precrrn-2_mtase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SNV04538.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000215383};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNV04538.1}.
FT DOMAIN 4..211
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 235 AA; 25884 MW; FD6C2F59D47B8DF6 CRC64;
MAGTFYGIGV GPGDPELLTM KAIKAIEKAD VLIAPKTEKK DGSVALSIAK PYLKKDIEIV
YQVFPMVVNF ETTDAWQKNK EEILALLQAG KNVVFLTLGD PMFYSTYIYV YRLLAKEKDI
NIETIPGVPA FCAIGSKLGY PLVEGNDIIS VIPATADKET IDKALAVSNN VVMMKVYKNY
PEIVDALTDN DMIENAVLVS RCGLPDEEVI TDLPAQKDKK LNYLSTILTR RSKSV
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