ID A0A239X2Y8_9FLAO Unreviewed; 1557 AA.
AC A0A239X2Y8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=dnaE_1 {ECO:0000313|EMBL:SNV40776.1};
GN ORFNames=SAMEA4412677_00823 {ECO:0000313|EMBL:SNV40776.1};
OS Chryseobacterium taklimakanense.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=536441 {ECO:0000313|EMBL:SNV40776.1, ECO:0000313|Proteomes:UP000215196};
RN [1] {ECO:0000313|EMBL:SNV40776.1, ECO:0000313|Proteomes:UP000215196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13490 {ECO:0000313|EMBL:SNV40776.1,
RC ECO:0000313|Proteomes:UP000215196};
RG Pathogen Informatics;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; LT906465; SNV40776.1; -; Genomic_DNA.
DR KEGG; ctak:4412677_00823; -.
DR Proteomes; UP000215196; Chromosome 1.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:SNV40776.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000215196};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNV40776.1}.
FT DOMAIN 1..191
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT DOMAIN 249..348
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1557 AA; 177228 MW; 6A6092EAFA41F46B CRC64;
MYLVFDTETT GLPNNFNAPV SDSGNWPRMV QIAWQLHDDE GNLIENQDYI IKPEGYDIPF
NASRIHGITT KLANEEGRDL AEVLQEFNEV LKKAKFGVGQ NVEFDYKIIG AEFFRKEIEN
SLQDLPKADT MIFGTEYCAI PSGKEGKFKS PKLEEIYEKL YGHKFDEAHN AAADVNATAQ
VFFEMLRIGV INASYLKISE DLIRNFRAAN PNPIKPFGIV IRRQVAASKT KKRTVDFGDT
PEVELGSYFN FHNHSIYSSL QASTDISDLI KKALYNNFPA VGMVDLGNMM GAFKFVSEVE
KANGAIKNSA KEYFAKKDEA EQNGEEFSEP EPRKELIPVL GCEFYISDRP EQKTFTKDDP
DRRTNVVLLA KNFNGYKNLA KLSSLGYVNG FYFGVPRISR KMIAEYKEDV IALTAGTFGD
IPNTILEFGE QKGEELFRWW KDTFGEDFYV QIQNHEVVEE EHVNDVLLGF ADKYDVKILA
QNETFYTEKS DANIQDILYC IKDGEKLSTP VGKGFGKRRG LPSSEYYIKD EAELKQTFRN
YPDAFEAYGE FLQKFEPYTL KRDVLLPKFD IPAEFFSEED EKDGGKRGEN AYLRHLTYEG
AKAKYGEITP EIADRLDFEL EVIENTGYPG YFLIVQDFCN EARKMGVSVG PGRGSAAGSA
VAYCIGITNV DPIKYDLLFE RFLNPERISM PDIDIDFDDE GRDRVIKWVV EKYGKTNVAQ
IITYSVLGGK SAIKDAGRVL DVPIPDTNNI AKLVPPSPGM NIAKAFSKYE KLPPEDKILV
DEMKKILEDK GDYRHSVLAS AQKMEGAIRN TGIHACGVII TPEDISNLVP ITIAAKDADI
IVSQFDNSVA ESAGLLKMDF LGLRTLTIIK DAIKLVKANH GIEIDTDEIP LDDEKTYQLF
QEGRTVGIFQ YESPGMQKYM RELKPTVFAD LIAMNALYRP GPIKYIPNFI NRKHGVEEIV
YDLPENEEYL AETYGITVYQ EQVMLLSQKL ANFTKGEADT LRKAMGKKQK DVLDKMYPKF
LEGGKSNNLD EAKLNKIWKD WEAFAEYAFN KSHSTCYALI AYHTAYLKAN YPAEYMASVM
THNLNNTKQI TMFMEDCKNM GVDVLGPDVN ESQYEFAVND KGQIRFGLGA IKGIGEGPSE
AIVESRKAGR YNTVLEFFER IPSSQINKRV VESLVMAGAF DEIDKYHRAQ YFDIDNAGRT
NIERLLRYGQ SFQDNKNEVE NSLFADFADE VKIEPPKISP APEWPNMYKL NKEKEIIGFY
LSAHPLDEFK YQYQFITGAL SRKEILEGKK DEEITVEKVI APVENDEDDI PEEVIDLELA
EDGEIIEEEP VKNVEARGNF NFLNLDEIDA FRDKNFGAEQ IKLFEEIKDF KEKQKFNSNA
KEFMVAGLIT EYTVRDGYNS GEKVAFMTLE DYTGSYSFRL GDRDYLKLRD KLDVQRFVIL
KIKFSLTAGK KDKQGKVLSE GRAFVNITDV IDLKEAFEKY AKSISVVMDV NDLRKDDLDF
LVKTFEEHRG EKKLHFFIKN PEENSHLELV SLRTKIDVNG DLLEIFGKEN KYEFFLN
//
