ID   A0A240ALS8_CLOCO        Unreviewed;       465 AA.
AC   A0A240ALS8;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Na(+)-linked D-alanine glycine permease {ECO:0000313|EMBL:STA93177.1};
GN   ORFNames=NCTC2909_01770 {ECO:0000313|EMBL:STA93177.1};
OS   Clostridium cochlearium.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1494 {ECO:0000313|EMBL:STA93177.1, ECO:0000313|Proteomes:UP000253892};
RN   [1] {ECO:0000313|EMBL:STA93177.1, ECO:0000313|Proteomes:UP000253892}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC2909 {ECO:0000313|EMBL:STA93177.1,
RC   ECO:0000313|Proteomes:UP000253892};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; UFWH01000001; STA93177.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A240ALS8; -.
DR   Proteomes; UP000253892; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        20..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        147..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        181..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        240..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        349..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        396..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        423..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   465 AA;  49181 MW;  126B92CDA13BCB0C CRC64;
     MEKALQIFNK IDSLVWGPPL LVLLVGTGIY LSIRLGFLQI GKLPLALKYL FKKGDDDSTG
     EGDVTSFQAL CTALAATIGT GNIVGVATAI KAGGPGAIFW MWVAAFFGMA TKYAEGLLAV
     KYRVTDKNGQ MSGGPMYYIE RGLGKKWLAK MFAIFGIGVA FFGIGTFAQI NAISESFKDS
     FGVPVVITGI IITILVAAVT LGGINSIAKV AEKIVPFMAI LYVTASVIII VTNAKLVPAA
     VVLIIKSAFN PTAAMGGFLG ATIKQAIQNG VARGVFSNES GLGSAPIASA AAKTKSCVRQ
     GLISMTGTFI DTIVICTMTG ITLVLTGMWK SDLAGAAMTN AAFVQGMPLP ILGKLIISIG
     LAFFAFTTIL GWNYYGERCT EYLFGIKGIK PYRYTFIAIV AIGGLSILKL DLIWVIADIV
     NGLMAIPNLI GLIGLSGVVV SETKKYFNNM NEEEVVEEAR RAIAR
//