ID   A0A240DXP2_9BURK        Unreviewed;       336 AA.
AC   A0A240DXP2;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=SAMN06295945_0288 {ECO:0000313|EMBL:SNX27969.1};
OS   Polynucleobacter meluiroseus.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=1938814 {ECO:0000313|EMBL:SNX27969.1, ECO:0000313|Proteomes:UP000218069};
RN   [1] {ECO:0000313|Proteomes:UP000218069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AP-Melu-1000-B4 {ECO:0000313|Proteomes:UP000218069};
RA   Varghese N., Submissions S.;
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; OANS01000001; SNX27969.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A240DXP2; -.
DR   OrthoDB; 9783139at2; -.
DR   Proteomes; UP000218069; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          6..72
FT                   /note="Winged helix-turn-helix transcription repressor HrcA
FT                   DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03444"
FT   DOMAIN          102..320
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   336 AA;  36579 MW;  1D564FD01BBB0A6C CRC64;
     MDDRSRALLK TLIERYIEEG QPIGSQSLSR SSGLDLSAAT IRNVMADLEE LGLVTSPHTS
     AGRIPTPRGY RLFVDTMLTV RPIEAITARE VEQGLLPDSP QRVLSSAAQI LSNLTHFAGV
     VMTPKRAQVF KHIEFLRLGE GKILLILVTP EGDVQNRILP TTQDYSPSQL TEAGNYINSQ
     FAGKSFAEVR AHLLSDLDHL RADIAGLMAL ALHSGESDYG MGHSEVVLSG ERRLLNIGDL
     SSNLDKLRKM FDMLEQKSVL VQLLDTSSHA DGIQIFIGGE SDLLPYEDLA VISAPYSIDG
     QIVGTLGVIG PTRMAYDRVI PIVDITSKLL SGALSY
//