ID   A0A241W027_9GAMM        Unreviewed;       297 AA.
AC   A0A241W027;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=B9T31_05645 {ECO:0000313|EMBL:OTG87088.1};
OS   Acinetobacter sp. ANC 4558.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=1977876 {ECO:0000313|EMBL:OTG87088.1, ECO:0000313|Proteomes:UP000194907};
RN   [1] {ECO:0000313|EMBL:OTG87088.1, ECO:0000313|Proteomes:UP000194907}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ANC 4558 {ECO:0000313|EMBL:OTG87088.1,
RC   ECO:0000313|Proteomes:UP000194907};
RA   Nemec A., Radolfova-Krizova L.;
RT   "High diversity of culturable Acinetobacter species in natural soil and
RT   water ecosystems.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTG87088.1}.
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DR   EMBL; NEGH01000003; OTG87088.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A241W027; -.
DR   STRING; 1977876.B9T31_05645; -.
DR   OrthoDB; 9786703at2; -.
DR   Proteomes; UP000194907; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          8..168
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          171..290
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        177
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   297 AA;  32299 MW;  A33600C25A66DA56 CRC64;
     MSLKSEVIGF IGLGMMGLPM VQQINKHGYK IYVSDLDHAK VDKALSFDGI EQLDLNRLHQ
     IDILITMLPN SNIVEKALLG DEDRDGVCAQ LRENTVIIDM SSSEPLRSRA LAKTLSLKGF
     QYLDAPVSGG VKKAVSGEIT IMVGGPRQLF NEHIALLKSM GSKIIYVGTS GSGHAAKALN
     NYVSAAAMTA TIEALKVAEK FGIDPDIMTD VLNSSSGKTN ASENKIKQFV LNETYASGFS
     LILMNKDLNI AKNLTENLQF NLPLSDAVFK FWNTSAKECQ ANVDHTEIYK KIGNLDG
//