ID   A0A242CJ95_9ENTE        Unreviewed;       732 AA.
AC   A0A242CJ95;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=HD domain-containing protein {ECO:0000313|EMBL:OTO10314.1};
GN   ORFNames=A5880_000998 {ECO:0000313|EMBL:OTO10314.1};
OS   Enterococcus sp. 4G2_DIV0659.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1834181 {ECO:0000313|EMBL:OTO10314.1, ECO:0000313|Proteomes:UP000195139};
RN   [1] {ECO:0000313|EMBL:OTO10314.1, ECO:0000313|Proteomes:UP000195139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4G2_DIV0659 {ECO:0000313|EMBL:OTO10314.1,
RC   ECO:0000313|Proteomes:UP000195139};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genomic Center for Infectious Diseases;
RA   Earl A., Manson A., Schwartman J., Gilmore M., Abouelleil A., Cao P.,
RA   Chapman S., Cusick C., Shea T., Young S., Neafsey D., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Enterococcus sp. 4G2_DIV0659.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTO10314.1}.
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DR   EMBL; NGLE01000001; OTO10314.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A242CJ95; -.
DR   STRING; 1834181.A5880_000998; -.
DR   OrthoDB; 9806952at2; -.
DR   Proteomes; UP000195139; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        372..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          510..653
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   732 AA;  83398 MW;  03D4FE02F02B5FC3 CRC64;
     MKYSLLKLRD KLGKAYIPIL LLIFSCFLFI IMFGSVHQKK VEIKEGQLAE NTIRATKNVE
     NTYETAAKKK LAAEAITPEY TYQEETADIQ HKRIEKLFKL ITAVNEKIDK DYQDKQAKAK
     KDETIPKPTV EERVASLKAQ FESLDQEEVT FYQKFPNSFY QNIFALNPDQ IGQVKAESLK
     IVDEKMKDHV RENELGNIRQ DAIEKIQFLD VSPTMQQEIR YVVNQGIVAN DFPNDKKTKE
     LRQNAMDAVP PAMIYQGEII VREGTQIDSK AMEKLELLGM TNQNTSIFPM VALTLAIVLQ
     VIVLLFFTKQ VTEEGKRRHF ILFYVGAMSL SILLMKFFQI FQTEQMMYIS LFFPAAFTPL
     VLNYFVNRRA GVLAAVFQVV FALFVFYHSI GTNSLTIILV SYLFSGLFAT VVKRTRISEQ
     GVVAVFWVII FPVCMDFILM VYQGMSLLDS KSWIMLICAL AGAVLSFLAT MGLHPYVELL
     VTDDSMIVLN ELSNPNHPLL KQLLEEAPGT YHHSMMVASL SANAVAEIGG RSLLTRVACY
     YHDIGKIKHA NFFVENLPAG AENPHNFLLP EDSKQIIFGH VADGAKILEE HHMPEMVIDI
     CRQHHGTTLM KFFYFKAKER NSEILEEDFR YPGPKPQTRE AGIVSIADTC EAAVRAMDHP
     TNDKIQSFVH NVIEDRISDG QLDECGLTMK EIRMVEKSLV SGLCSTFHSR IKYPKMKSEA
     EKMKDEQEKR DD
//