ID A0A243PJK3_9SPHN Unreviewed; 382 AA.
AC A0A243PJK3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=MexE family multidrug efflux RND transporter periplasmic adaptor subunit {ECO:0000313|EMBL:OUC56792.1};
GN ORFNames=CA262_09860 {ECO:0000313|EMBL:OUC56792.1};
OS Sphingobium sp. GW456-12-10-14-TSB1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1987165 {ECO:0000313|EMBL:OUC56792.1, ECO:0000313|Proteomes:UP000194660};
RN [1] {ECO:0000313|EMBL:OUC56792.1, ECO:0000313|Proteomes:UP000194660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GW456-12-10-14-TSB1 {ECO:0000313|EMBL:OUC56792.1};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUC56792.1}.
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DR EMBL; NGUN01000003; OUC56792.1; -; Genomic_DNA.
DR RefSeq; WP_026002585.1; NZ_NGUN01000003.1.
DR AlphaFoldDB; A0A243PJK3; -.
DR OrthoDB; 9816569at2; -.
DR Proteomes; UP000194660; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..382
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011305396"
FT DOMAIN 32..354
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 59..286
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 382 AA; 40068 MW; 415025BB164F811A CRC64;
MQKGKFIGLL ACASALTLSA CGDSPPPAPP PPAVGVVTLE TGTAPLINEL PGRIVAVETA
EVRPQISGVI RRRLFAEGGM VRAGQLLYEI EDAPYRAAVA QAQGALARAN AAIRATSLQA
QRYKDLVGIN AVSRQEYDNA DAAAQQARAD VAAQRGALQS AQVNQNFTRI RAPISGRIGR
SLFTPGALVQ AGQADPLATI QRTDTVYVDV TQSAAEIIDL KQAMKKGGVS SVDGARIQLL
LPNGSTYPIE GRLQFSEVSV DPTSGAVTLR ATFANPDGLL LPGMYVRARV VEGQRRQVIL
APQQGISRDA RGRATALVVG KDNKAELRQV TVDRPVGDKW IVTGGLKPGD RLIVEGLLNL
RAGTVVKPGA PQQVTASNGG AQ
//
