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Database: UniProt
Entry: A0A243RU13_9ACTN
LinkDB: A0A243RU13_9ACTN
Original site: A0A243RU13_9ACTN 
ID   A0A243RU13_9ACTN        Unreviewed;       320 AA.
AC   A0A243RU13;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569, ECO:0000256|RuleBase:RU366046};
DE            EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN   ORFNames=CA983_28995 {ECO:0000313|EMBL:OUC98590.1};
OS   Streptomyces swartbergensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=487165 {ECO:0000313|EMBL:OUC98590.1, ECO:0000313|Proteomes:UP000195105};
RN   [1] {ECO:0000313|EMBL:OUC98590.1, ECO:0000313|Proteomes:UP000195105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMC13 {ECO:0000313|EMBL:OUC98590.1};
RA   Le Roes-Hill M., Prins A., Durrell K.A.;
RT   "Biotechnological potential of actinobacteria isolated from South African
RT   environments.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC         ECO:0000256|RuleBase:RU366046};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911,
CC         ECO:0000256|RuleBase:RU366046};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUC98590.1}.
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DR   EMBL; NGFN01000225; OUC98590.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A243RU13; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000195105; Unassembled WGS sequence.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   NCBIfam; TIGR01179; galE; 1.
DR   PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR   PANTHER; PTHR43725:SF45; UDP-GLUCOSE 4-EPIMERASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW   Isomerase {ECO:0000256|RuleBase:RU366046};
KW   NAD {ECO:0000256|RuleBase:RU366046}.
FT   DOMAIN          6..241
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   320 AA;  33805 MW;  3FA6B2194765C6D3 CRC64;
     MSGKYLVTGG AGYVGSVVAQ HLLEAGHEVH VLDNLSTGFR EGVPAGATFV EGDIRDAAKW
     LDSSFDGVLH FAAFSQVGES VVKPEKYWDN NVGGTMALLA AMREAGVRTL VFSSTAATYG
     EPEQVPIVES APTAPTNPYG ASKLAVDHMI TGEAAAHGLG AVSLRYFNVA GAYGEYGERH
     DPESHLIPLV LQVAQGRREA ISVFGDDYPT PDGTCVRDYI HVADLAEAHL LALKAAAPGE
     HLICNLGNGN GFSVREVIET VRRVTGHPIP EVVAPRRGGD PAVLVASAAT AREKLGWNPS
     RADLDGIVAD AWDFAQRRGN
//
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