ID A0A243RXI0_9ACTN Unreviewed; 568 AA.
AC A0A243RXI0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=CA983_28140 {ECO:0000313|EMBL:OUC99243.1};
OS Streptomyces swartbergensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=487165 {ECO:0000313|EMBL:OUC99243.1, ECO:0000313|Proteomes:UP000195105};
RN [1] {ECO:0000313|EMBL:OUC99243.1, ECO:0000313|Proteomes:UP000195105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMC13 {ECO:0000313|EMBL:OUC99243.1};
RA Le Roes-Hill M., Prins A., Durrell K.A.;
RT "Biotechnological potential of actinobacteria isolated from South African
RT environments.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUC99243.1}.
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DR EMBL; NGFN01000214; OUC99243.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A243RXI0; -.
DR Proteomes; UP000195105; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OUC99243.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OUC99243.1}.
FT DOMAIN 15..241
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 300..530
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 59..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 59428 MW; 9A3108D4D52BE2AB CRC64;
MSPTTLSAGP EHGHVTFLGA GPGDPGLLTL RAVEALAHAD VLVAEHEVLD VVRQHARQGV
SEVNTDSDPS QEPGPGTGAP QLTVVDGTST AVAAPAVRDA AHLVMEAARG GRRVVRAVSG
DPGLDTYAAE EMLACAAAGV PFEVVPGIAS AVGVPAYAGV PLRDAQGADV RFVDARTASD
RCWTEVGASD GTVVVSTTLD SVSAAAGELV SAGRKPDTPM TVTVAGTTTR QRTWSATLGT
IAQTLKQAKV LPSPDGGRPV IAVVGERSAA AQRDQLAWFE SKPLFGWKVL VPRTKEQAAS
LSDQLRSYGA VPYEVPTIAV EPPRTPQQME RAVKGLVTGR YEWIAFTSVN AVKAVREKFE
EYGLDARAFA GIKVAAVGEQ TAKALIAFGV KPDLVPSGEQ SAAGLLEDWP PYDPVFDPID
RVFLPRADIA TETLVAGLIE LGWEVDDVTA YRTVRASPPP AETREAIKGG GFDAVLFTSS
STVRNLVGIA GKPHNVTVIA CIGPATCKTA EEHGLRVDVM APEPSVHKLA EALADFGAKR
RAAALEAGDP VTRPSERRPG ARRRRSTT
//
