ID   A0A243S038_9ACTN        Unreviewed;       335 AA.
AC   A0A243S038;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase {ECO:0000313|EMBL:OUD00823.1};
DE   Flags: Fragment;
GN   ORFNames=CA983_23400 {ECO:0000313|EMBL:OUD00823.1};
OS   Streptomyces swartbergensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=487165 {ECO:0000313|EMBL:OUD00823.1, ECO:0000313|Proteomes:UP000195105};
RN   [1] {ECO:0000313|EMBL:OUD00823.1, ECO:0000313|Proteomes:UP000195105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMC13 {ECO:0000313|EMBL:OUD00823.1};
RA   Le Roes-Hill M., Prins A., Durrell K.A.;
RT   "Biotechnological potential of actinobacteria isolated from South African
RT   environments.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|ARBA:ARBA00001938};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUD00823.1}.
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DR   EMBL; NGFN01000153; OUD00823.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A243S038; -.
DR   Proteomes; UP000195105; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR014276; 2-oxoglutarate_DH_E2.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   NCBIfam; TIGR02927; SucB_Actino; 1.
DR   PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR   PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR   SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000313|EMBL:OUD00823.1}.
FT   DOMAIN          29..66
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:OUD00823.1"
SQ   SEQUENCE   335 AA;  34443 MW;  3AA591DC71EDBBC0 CRC64;
     APSAPVPAPA PAQAPAAPAA AQPADDGAYV TPLVRKLAAE HGVDLSTVKG TGVGGRIRKQ
     DVMSAAEAAK AAAAAPAPAA AAPAAAKKAP TLEASPLRGQ TIKMPRIRKV IGDNMVKALH
     EQAQLSSVVE VDVTRLMKLR ARAKDAFAAR EGVKLSPMPF FVKAAAQALK AHAPINAKIN
     EAEGTITYFD TENIGIAVDS EKGLMTPVIK NAGDLNLAGI AKATAELAGK VRANKITPDE
     LSGATFTISN TGSRGALFDT IIVPPGQVAI LGIGATVKRP AVIETEEGTA IGVRDMTYLT
     LSYDHRLVDG ADAARYLTAV KAILEAGEFE VELGL
//