ID   A0A243S963_9ACTN        Unreviewed;       647 AA.
AC   A0A243S963;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Heparinase {ECO:0000313|EMBL:OUD04158.1};
GN   ORFNames=CA983_05780 {ECO:0000313|EMBL:OUD04158.1};
OS   Streptomyces swartbergensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=487165 {ECO:0000313|EMBL:OUD04158.1, ECO:0000313|Proteomes:UP000195105};
RN   [1] {ECO:0000313|EMBL:OUD04158.1, ECO:0000313|Proteomes:UP000195105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMC13 {ECO:0000313|EMBL:OUD04158.1};
RA   Le Roes-Hill M., Prins A., Durrell K.A.;
RT   "Biotechnological potential of actinobacteria isolated from South African
RT   environments.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUD04158.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NGFN01000020; OUD04158.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A243S963; -.
DR   Proteomes; UP000195105; Unassembled WGS sequence.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.70; -; 1.
DR   Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR   InterPro; IPR008929; Chondroitin_lyas.
DR   InterPro; IPR012480; Hepar_II_III.
DR   InterPro; IPR031680; Hepar_II_III_N.
DR   PANTHER; PTHR39210; HEPARIN-SULFATE LYASE; 1.
DR   PANTHER; PTHR39210:SF1; HEPARIN-SULFATE LYASE; 1.
DR   Pfam; PF07940; Hepar_II_III; 1.
DR   Pfam; PF16889; Hepar_II_III_N; 1.
DR   SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          122..324
FT                   /note="Heparin-sulfate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16889"
SQ   SEQUENCE   647 AA;  71084 MW;  7DC9471460720A50 CRC64;
     MTMSAGWYLR RLSRMGPREV GGRAVDAVRR RRWRSARPAC PSVTGARFTA VLPAGTIAAI
     PPDAAKRLIA EADRLMYGHA EYFGVVRDDL ADPDWWYDPR TGRRAPWGYA FDVPYRNEDA
     VGDIKQIWEL SRHQYLTVLA AAYAITGNER YAERVAEHLR SWWAANSPLR GVHWISGIEL
     GIRLLSWVWI RRLLDGWPGA AGLFEGNSVA VNQIWHHQRW LAAFPSRGSS ANNHVIAEAA
     GQFAAACAFG WFPSSERWRA DALRSLERHL RSNTFDSGLN RELATEYHGL VLELGLAAVA
     EADAAGVPVP ASIRTVLLRM TDTLAAVVDS RLRPPRQGDA DDGHGLVVDG AGTDRWASLL
     ATGDAVFGRL AWWPTVTGTD VRTPLLAALI KPAELSVIRP ATRPAHFADA GMTILRGPGE
     IWCRCDGGPH GFLSIAAHAH ADALSVEVRH DGVDVLADPG TFCYHGQPEW RQYFRSTLGH
     NTLQLDGTDQ SVSGGPFLWI RHARSRVLTA DTSGEGVAHW CAEHDGYQRS VHRRRVELTA
     ASQELRVVDE VRGPSRDVRL AFHLGPAIAA DLVGNRAVLT WIRDGEGRSA VLDLPGQLSW
     RAHRGETDPP LGWYSAGFGR REPSTTLVGT GFAEGAEGFT TVLRFRG
//