ID A0A243WHY0_9BACT Unreviewed; 582 AA.
AC A0A243WHY0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DNA polymerase/3'-5' exonuclease PolX {ECO:0000313|EMBL:OUJ75428.1};
GN ORFNames=BXP70_05285 {ECO:0000313|EMBL:OUJ75428.1};
OS Hymenobacter crusticola.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1770526 {ECO:0000313|EMBL:OUJ75428.1, ECO:0000313|Proteomes:UP000194873};
RN [1] {ECO:0000313|EMBL:OUJ75428.1, ECO:0000313|Proteomes:UP000194873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIMBbqt21 {ECO:0000313|EMBL:OUJ75428.1};
RA Liang Y., Feng F.;
RT "A new Hymenobacter.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUJ75428.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MTSE01000002; OUJ75428.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A243WHY0; -.
DR OrthoDB; 9808747at2; -.
DR Proteomes; UP000194873; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07436; PHP_PolX; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.10.150.110; DNA polymerase beta, N-terminal domain-like; 1.
DR Gene3D; 3.30.210.10; DNA polymerase, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR002054; DNA-dir_DNA_pol_X.
DR InterPro; IPR010996; DNA_pol_b-like_N.
DR InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR InterPro; IPR037160; DNA_Pol_thumb_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR022311; PolX-like.
DR InterPro; IPR047967; PolX_PHP.
DR PANTHER; PTHR36928; PHOSPHATASE YCDX-RELATED; 1.
DR PANTHER; PTHR36928:SF1; PHOSPHATASE YCDX-RELATED; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF14716; HHH_8; 1.
DR Pfam; PF02811; PHP; 1.
DR PIRSF; PIRSF005047; UCP005047_YshC; 1.
DR SMART; SM00278; HhH1; 2.
DR SMART; SM00481; POLIIIAc; 1.
DR SMART; SM00483; POLXc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
PE 4: Predicted;
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Exonuclease {ECO:0000313|EMBL:OUJ75428.1};
KW Hydrolase {ECO:0000313|EMBL:OUJ75428.1};
KW Nuclease {ECO:0000313|EMBL:OUJ75428.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000194873}.
FT DOMAIN 1..310
FT /note="DNA-directed DNA polymerase X"
FT /evidence="ECO:0000259|SMART:SM00483"
FT DOMAIN 90..109
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 125..144
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 334..413
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 582 AA; 65093 MW; ACF5A47036679110 CRC64;
MDNRALIRAF RLAASLLELH DENPFKIRAY EGTAAALERL EFPVAEIERT GLPDRTGLSK
TAAARVAELL DTGSFDELTR LLSITPPGVV EMLNIKGIGP KKIRALWREL GIESPDALRD
AAEQDRVSKL KGFGKKTQDA ILQALEFSQE SRGKLLYPQA EELGNDLAAR LQETLFTDQV
AVVGEVRRRL EVIETVCLVA ATSQPWKAQE MLNGLDGLTA DPTRSGPFAW RGAATASGVK
VEVYLVKKED YTNQLFLLTG AEAHLTELIP DALPGQPSSL RQVVKREQFY QETAIYQKAG
LQYVEPELRE GLGEIVLAKA QKLPKLLEDS DLRGSLHNHS TYSDGSHTLR QMAEFLRDNG
YEYLGICDHS QAAHYANGLN PDRVRQQQRE IEQLNQELAP FRIFKGIESD ILGDGALDYA
PDVLASFDFI VASVHSNLKM DEQRATNRLL RAIENPYTTM LGHPTGRLLL RREGYPINYK
AVIDACAQHN VIIEINANPW RLDLDWRWVR YALDQGVKLS INPDAHHTNG YADMRYGVMM
GRKGGLTKEM TFNALSGDEM ATYFAERKAN IKPAEAFKTT LF
//
