ID A0A244E1D8_9BURK Unreviewed; 2147 AA.
AC A0A244E1D8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=P/Homo B domain-containing protein {ECO:0000259|PROSITE:PS51829};
GN ORFNames=A8M77_33640 {ECO:0000313|EMBL:OUL98047.1};
OS Variovorax sp. JS1663.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1851577 {ECO:0000313|EMBL:OUL98047.1, ECO:0000313|Proteomes:UP000195166};
RN [1] {ECO:0000313|EMBL:OUL98047.1, ECO:0000313|Proteomes:UP000195166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS1663 {ECO:0000313|EMBL:OUL98047.1};
RX PubMed=28526789;
RA Mahan K.M., Zheng H., Fida T.T., Parry R.J., Graham D.E., Spain J.C.;
RT "A novel, iron-dependent enzyme that catalyzes the initial step in the
RT biodegradation of N-nitroglycine by Variovorax sp. strain JS1663.";
RL Appl. Environ. Microbiol. 83:0-0(2017).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUL98047.1}.
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DR EMBL; LYMK01000086; OUL98047.1; -; Genomic_DNA.
DR Proteomes; UP000195166; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.40.2810; -; 1.
DR Gene3D; 1.10.10.1280; Alpha-helical porin B/porin C; 6.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 7.
DR InterPro; IPR041910; Alpha_h_PorB/PorC.
DR InterPro; IPR041690; Cadherin_5.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR010566; Haemolys_ca-bd.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR013858; Peptidase_M10B_C.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF17892; Cadherin_5; 1.
DR Pfam; PF06594; HCBP_related; 1.
DR Pfam; PF00353; HemolysinCabind; 9.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF08548; Peptidase_M10_C; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00313; CABNDNGRPT.
DR SUPFAM; SSF51120; beta-Roll; 7.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 9.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000195166};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 669..816
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
SQ SEQUENCE 2147 AA; 219181 MW; 05EF3A499D667246 CRC64;
MLLVDAADTF LDGGEGLDVV QVVGSAGVTL DMAESHIEIA VGGDGADTFV GGGRSSVFVR
GGAGDDLIIG GAANDALSGE DGSDVIDGGA GNDLIRGHRG RDQLLGGAGD DVLDGGLEDD
ALGGGSGNDV LTGGRGDDSL NGGDGIDVAQ YAGSYADYRI SRISDANGST RYRVVDIRTG
ADGADTLTDI EKLSFSDISR VDLTLGSPLP VKDVLTVDST GQALGRSAAH LISKNQLLAN
DRDWDSATSQ LSITAVLEAR GGTVSLTQNG DVLFTPDPTY SGVMSFKYRI KDNANHVTEI
TNGATGQSEV MKGAVYLQTA DLKDAQGRVD PLLLEQWYLS DVNVMPVWQD YSGKGVRIGQ
FEPGGAYSTG PEVFDYRHPD LQPNADKVWL NMLDGTGHSN TPETFSSHAT MVAGVMVAAR
NGEGGVGVAY NARLAGHYIQ GEGLEVRQLD SEISSALARF RDYDVVNNSW GPKGSFGLNV
VPVGALESNI AAAVSQGRNG LGTAIVMAGG NDRATGANTN YNALTANRAV IVAGSINAPG
DLGSLQVGAR PFSNPGASIL VSAPGSNIES TSRELIASNG STFGSDYNTS QGTSFAAPIV
SGVIALMLEA NPGLGYRDIQ TILAMSATKV NDPNGTDWAT NTARTWNGGG MHVSHDYGFG
KVDARAAVRL AEAWTEQNTF GNEYTTSASS GAILAAIPDG SGMLTRTLSM GGGLEVESAQ
VTLELDHQRW GDLIVKLISP TGTESVLVNR PGKAPGSAAS DRGDASSGIL SFSFNSTRLL
GEQSAGTWTL QVLDAATGQV GTLKNWKLDL YGKAADTNDV YVYTNEFATF AGAARGTLTD
SNGGRDTLNA SAVTGNSVIN LNNGSTSTLA GKSLAVSGDI EIAFGGDGDD TLTGNATSNV
LLGGRGADLI HGGDGNDTLD GGKGSDLLTG GAGSDLFVIG KDPGAQDAIV DLWTGTGGAV
VETIAFVGFG GLRFDTLSRT QVGADVRLDL GDGQTVLLRN QQANQLAAAQ FQFFDSQAAL
QAWQLAGQGG GIGGPTEGDD VLQGTTGDDV LAGLGGNDTL AGNDGNDKLL GGSGRDALNG
GAGNDVLVLD GDQGAVSYAT GSAGPGARTG GTGADRFLVA PDGGGATAVG LSGADMTASN
LIRDFDLAVD KIDLSQFAWI TSFSQLTATK ALTINSTFIT RVSAQASGQP TVAVGLYGIE
PAALTAANFI FAGSADATPM PVSNASASTA AGAAPLAIVG ATAAAATQPP AISGTSADDM
LVGDAGANTL DGLAGADGMT GRTGDDTYVV DHAGDTISEL PGGGYDSVQS TVNYTLSANV
EALVLGGSAD LGAMGNDQRN RLAGNAGANR LDGAAEADDM VGGAGNDTYV VDNQLDTVFE
GDNEGVDSVE SAVSWTLGQN VENLVLTGSD HVNATGNALA NALTGNTGDN ILDGAEGADS
MAGGGGNDTY YVDNAGDAVA EALNGGLDTA HSSVNVSLGA NVENAVLFGA ATSAAGNVLD
NTLVGNGLAN TLSGDAGNDF LEGQGGDDAL YGGSGDDYLD GGRGRNALAG GLGNDTYVVG
STDSTGFQIG RWSTQQGGYS DAQRWFTADV NGDGKADLVN VFNDGGTMSA DAHISTGTGY
QIQRWATRQG GYWDAQRWSV ADVNGDGKAD LVNIYGESGA MSADAHISTG SGFQIQRWAT
RQGGYGDAQR WSVADVNGDG KADLVNIYGD NGAMSADAHI STGSGFQIQR WATQQGGYWD
AQRWSIADVN GDGRADLVNI YGESGAMSAD AHISTGSDFQ IQRWATRQGA YWDAQRWSLA
DVNGDGKADL VNIYGENGAM SADAHISTGS GFQIQRWATR QGGYWDAQRW SLADVNGDGK
ADLVNIYGEN GAMNADAHVS TGRGFQIQRW ATQQGGYSDS SQRWSLADAN GDGKSDLVNL
MNDGGSMSAD VHASGNAVDP RSDAITEQAG EGIDTVHSSS SHTLAPTLEN LILRGSEIAQ
GSGNASGNGL TGNAAMNTLK GYAGDDVLDG GGGDDFLLGG AGNDTYVLGR GHGVDRIGEN
DGTGGNTDVA LFNAGIAADQ LWFRQAGNDL EVSVIGTGDK FLIGNWYLGG AYHVEQFKTS
DGHVLQDSQV QNLVQAMASF SPPTAGQTTL LPSYQSSLNA VIAANWQ
//
