ID A0A244EET2_9BURK Unreviewed; 378 AA.
AC A0A244EET2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=4-hydroxybutyrate dehydrogenase {ECO:0000313|EMBL:OUM02995.1};
GN ORFNames=A8M77_08620 {ECO:0000313|EMBL:OUM02995.1};
OS Variovorax sp. JS1663.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1851577 {ECO:0000313|EMBL:OUM02995.1, ECO:0000313|Proteomes:UP000195166};
RN [1] {ECO:0000313|EMBL:OUM02995.1, ECO:0000313|Proteomes:UP000195166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS1663 {ECO:0000313|EMBL:OUM02995.1};
RX PubMed=28526789;
RA Mahan K.M., Zheng H., Fida T.T., Parry R.J., Graham D.E., Spain J.C.;
RT "A novel, iron-dependent enzyme that catalyzes the initial step in the
RT biodegradation of N-nitroglycine by Variovorax sp. strain JS1663.";
RL Appl. Environ. Microbiol. 83:0-0(2017).
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00007358}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUM02995.1}.
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DR EMBL; LYMK01000007; OUM02995.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A244EET2; -.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000195166; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd14861; Fe-ADH-like; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000195166}.
FT DOMAIN 8..369
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 378 AA; 39979 MW; 5A2CA42E8D339573 CRC64;
MALIQYLTQI QFDFGAVRLL RSECERIGIR RPLIVTDTGV RAAGILQKAV DALEGLPHAV
FDATPSNPTE AAVRAAAALY RDQGCDGLVA VGGGSAIDCA KGVAIAATHD GPLKTYATIE
GGSPKITESV APLIAIPTTS GTGSEVARGA IVIVDDHRKL GFHSWFLMPK AAICDPELTL
GLPPRLTAAT GMDAIAHCME TFMSAAFNPP ADGIGLDGLQ RAWRYIERAT KDGSDREARL
NLMSASMQGA MAFQKGLGCV HSLSHSLGGI DPRLHHGTLN ALFLPAVITF NAGAESVQKE
QRLQRMAQAM NLDSAGDLGA AIRDMNARLG LPKGLAEVGV STEMFEPIID GAMADHCHKT
NPRLATRDDY RAMLEASM
//
