ID A0A245ZIV6_9SPHN Unreviewed; 440 AA.
AC A0A245ZIV6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Methionine gamma-lyase {ECO:0000313|EMBL:OWK29657.1};
DE EC=4.4.1.11 {ECO:0000313|EMBL:OWK29657.1};
GN Name=mdeA {ECO:0000313|EMBL:OWK29657.1};
GN ORFNames=SPMU_20770 {ECO:0000313|EMBL:OWK29657.1};
OS Sphingomonas mucosissima.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=370959 {ECO:0000313|EMBL:OWK29657.1, ECO:0000313|Proteomes:UP000197783};
RN [1] {ECO:0000313|EMBL:OWK29657.1, ECO:0000313|Proteomes:UP000197783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17494 {ECO:0000313|EMBL:OWK29657.1,
RC ECO:0000313|Proteomes:UP000197783};
RA Poehlein A., Wuebbeler J.H., Steinbuechel A., Daniel R.;
RT "Genome sequence of Sphingomonas mucosissima DSM 17494.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK29657.1}.
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DR EMBL; NBBJ01000003; OWK29657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A245ZIV6; -.
DR OrthoDB; 9805807at2; -.
DR Proteomes; UP000197783; Unassembled WGS sequence.
DR GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF86; METHIONINE GAMMA-LYASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:OWK29657.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2}.
FT MOD_RES 250
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 440 AA; 46597 MW; FD4F79F30F9E25C3 CRC64;
MTKETEADLT GVEARVSPKP AVDEIGGRKL KPATLMMGHG YDPALSEGAL KPPIFLTSTF
VFPNAAAGKR HFEGVTGKRP GGAEGLVYSR FNGPNQEILE DRLSIWEDAE DALAFSSGMS
AIATLFLSMV KPGDTIVHSG PLYAATETLI ARILGRFGVH WLDFPAGATR EEIDAVLSKA
ASGNVALIYL ESPANPTNAL VDVEAVSASR DAIFTGANKP PIAIDNTFLG PLWHKPLRHG
ADLVVYSLTK YAGGHSDLVA GGVLGSKAHM DTIRLMRNTI GTICDPNTAW MLLRSLETLE
LRMSRAGENA AKVCAFLRDH SAVEKVGYLG FLEGGQDARQ ADIYRRHCNG AGSTFSLYLK
GGEAEAFAFL DALKIAKLAV SLGGTETLAS HPAAMTHLSV PDARKAALGI TDNLVRISIG
VEDADDLIAD FSQALDAIGG
//
