ID A0A246AE07_9SPHI Unreviewed; 348 AA.
AC A0A246AE07;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=CBW18_08875 {ECO:0000313|EMBL:OWK71174.1};
OS Pedobacter sp. AJM.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=2003629 {ECO:0000313|EMBL:OWK71174.1, ECO:0000313|Proteomes:UP000198039};
RN [1] {ECO:0000313|Proteomes:UP000198039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AJM {ECO:0000313|Proteomes:UP000198039};
RA Mcnett A.J., Newman J.D.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK71174.1}.
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DR EMBL; NHOT01000003; OWK71174.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A246AE07; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000198039; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OWK71174.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198039};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 31..79
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 92..297
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 348 AA; 39609 MW; 965A1C8DFCCF7A86 CRC64;
MVQGEDVVKA SGLVYVTDAM PGIYRKGKPG KFYYEDKKGN KITEERHLGR IKALVIPPAW
QNVWIANKPN AYLQVTGIDA AGRKQYRYHA KWTSRRSEDK YFRLFEFGKV LPEARKQIAK
DLKRKVLDER KVLAISVDVL QKSLIRVGNE NYKQLYGSFG LSTLRDKHVK IEGSKINIDF
IGKKGVRQTV VLNDSSLAKL VKKCRDIPGQ DLFQYYTDGK EHRGIDSGKI NNYIKEITQN
DFTAKDFRTW GGTLEALRQF AKCSVDVDVA LNTKKTVINV LDCVAKKLGN TRAVCKSSYV
YPLLITAYEN NELVKYMKKM NNHKTVGKLG LEHDEKVLLS FLKSTGSK
//
