ID A0A246BB78_9FLAO Unreviewed; 1045 AA.
AC A0A246BB78;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=AP75_03580 {ECO:0000313|EMBL:OWK98943.1};
OS Kaistella haifensis DSM 19056.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Kaistella.
OX NCBI_TaxID=1450526 {ECO:0000313|EMBL:OWK98943.1, ECO:0000313|Proteomes:UP000197587};
RN [1] {ECO:0000313|EMBL:OWK98943.1, ECO:0000313|Proteomes:UP000197587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19056 {ECO:0000313|EMBL:OWK98943.1,
RC ECO:0000313|Proteomes:UP000197587};
RG Genome Consortium for Active Teaching;
RA Sontag T.C., Newman J.D.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OWK98943.1, ECO:0000313|Proteomes:UP000197587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19056 {ECO:0000313|EMBL:OWK98943.1,
RC ECO:0000313|Proteomes:UP000197587};
RA Newman J.D.;
RT "Genome of Chryseobacterium haifense.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK98943.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JASZ02000004; OWK98943.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A246BB78; -.
DR Proteomes; UP000197587; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OWK98943.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OWK98943.1}.
FT DOMAIN 367..584
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 695..1038
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 1045 AA; 120057 MW; 4A0FB0A960D559AD CRC64;
MTIAQYIDNL DKRYRLGNAT EHTFRGDLQQ LLESLVVGIR ATNEPKRQSC GAPDYILTKN
DIPVGFIEAK DIGDKDLDGT KKTGNKEQFD RYKASLNNLL FTDYLSFHLY REGEFITKVS
IAEVGEKGIQ PIPENFIVFE NLIKDFCTHV GQTIKSPKKL AEMMAGKARL LSDVIGKALT
SDEANQEDST LKDQMTAFRD ILIHDITSKG FADVYAQTIA YGMFAARLHD PTLPTFSRHE
AAELIPKSNP FLRKLFGYIA GPDIDDRIKW IVDSLVEIFL ACNVEEILKD YGKATKMENP
IIHFYETFLS EYDPKLRKAR GVWYTPAPVV NFIVRAVDDV LKTEFGLSQG LADTSQTKIT
LDTQNFNAKK QKYDTVEKEV HKVQILDPAT GTGTFLAEVI QHIHKKFEGQ QGIWSNYVEK
HLIPRLNGFE LLMASYAMAH LQLDILLKDT GYKATNDDRL RVFLTNSLEE SHPDTNTLFA
NWLSDEANAA NRIKRDSPVM VILGNPPYSV SSSNKGEWIQ NLISDYKKNL NERKINLDDD
YIKFIRYGQH FIDKNGSGVL AYISNNSFID GITHRQMRKS LLETFDKIYI LDLHGNTRKL
ETSPDGSTDQ NVFDIMAGVS INIFIKKSKN QKNQFANVLH YDLYGVRNKK YEFLNNENIK
SIDWCEINSN EPNYFFVPKD FSNVETYESG FKLDELFSFS NSGFETAKDN FIVKFEKGSS
NKLKQDIELL TAEDLANKFG LKLSKSQEVK NDIINSSVIK ILYRPFDERF TLISKNSGGV
MFRPRFETVR HLLHNNIGLL CCKRQTSFDF QHTFITKLPV ERCSVSLQTG EVSYVFPLYL
YPETTLEGDA KRIPNLNMEI VENMAKNLGL HFSPEKPDYS QQTEEDSQFY PEDILDYIYA
VLHSPSYREK YKEFLKIDFP RVPYPKDAET FFKLVNLGRE IREIHLLESP VVENYITQYP
EDGDNVVNKP VYKDGRVYIN SSQYFEGVPE VAWNFYIGGY QPAQKWLKDR KGRTLDFDDI
LHYQKIIVAL AETDRLMKEI DQIGL
//
