ID A0A246FT25_9PSED Unreviewed; 486 AA.
AC A0A246FT25;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=CEC48_26755 {ECO:0000313|EMBL:OWP68693.1};
OS Pseudomonas sp. K2I15.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=2013577 {ECO:0000313|EMBL:OWP68693.1, ECO:0000313|Proteomes:UP000197956};
RN [1] {ECO:0000313|EMBL:OWP68693.1, ECO:0000313|Proteomes:UP000197956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K2I15 {ECO:0000313|EMBL:OWP68693.1,
RC ECO:0000313|Proteomes:UP000197956};
RA Orellana P., Castillo D., Corsini G.;
RT "Draft genome sequence of the Chilean Antartic Pseudomonas sp. strain
RT K2I15.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWP68693.1}.
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DR EMBL; NIXO01000065; OWP68693.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A246FT25; -.
DR OrthoDB; 9806359at2; -.
DR UniPathway; UPA00126; UER00930.
DR Proteomes; UP000197956; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:OWP68693.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:OWP68693.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OWP68693.1}.
FT DOMAIN 9..294
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 325..475
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 486 AA; 53446 MW; 3C31D0B9BBF34C50 CRC64;
MNALNGLIPC IISGGSGTRL WPVSRQNMPK PFMRMHDDQS LLQKTFLRAS HLPGVESVLT
VTNRDLLFRT LDDYRVVNKT HLALDLLLEP FGRNTAAAIA VAALHVQENF GGEAQLLILP
ADHLILDESA FADAVTQARE LAEAGYLVTF GIQPDRPETG FGYIEQGEAL GQGFRVKRFV
EKPDLATAQG YLDGGKHLWN AGMFCFKAST LLEELALHAP AVLDAAKAAL DHSHSLNNNN
CRQRELNAEG FGTAPDISID VALMEKSAQV AVVPCDIGWS DIGSWDAVRQ LTPSDANGNQ
VNGEAILHDV HNCYIDSPKR VLGAVGVSNL IIVDTPDAIL IADANRSQDV RYIVAELKRQ
NHPAFSLHRT VTRPWGTYTV LEESSRFKIK RIVVKPRASL SLQMHHHRSE HWVVVSGAAM
ITNGDREFLI NANESTYIPA GHKHRLTNPG IIDLVMIEVQ SGEYLGEDDI VRFDDIYGRA
PAEVKP
//