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Database: UniProt
Entry: A0A246JL75_9BURK
LinkDB: A0A246JL75_9BURK
Original site: A0A246JL75_9BURK 
ID   A0A246JL75_9BURK        Unreviewed;       698 AA.
AC   A0A246JL75;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OWQ93388.1};
GN   ORFNames=CDN99_02595 {ECO:0000313|EMBL:OWQ93388.1};
OS   Roseateles aquatilis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Roseateles.
OX   NCBI_TaxID=431061 {ECO:0000313|EMBL:OWQ93388.1, ECO:0000313|Proteomes:UP000197468};
RN   [1] {ECO:0000313|EMBL:OWQ93388.1, ECO:0000313|Proteomes:UP000197468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCUG 48205 {ECO:0000313|EMBL:OWQ93388.1,
RC   ECO:0000313|Proteomes:UP000197468};
RX   PubMed=18175673; DOI=10.1099/ijs.0.65169-0;
RA   Gomila M., Bowien B., Falsen E., Moore E.R., Lalucat J.;
RT   "Description of Roseateles aquatilis sp. nov. and Roseateles terrae
RT   sp. nov., in the class Betaproteobacteria, and emended description of
RT   the genus Roseateles.";
RL   Int. J. Syst. Evol. Microbiol. 58:6-11(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OWQ93388.1}.
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DR   EMBL; NIOF01000001; OWQ93388.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000197468; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000197468};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      297    473       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      478    570       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      606    693       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   698 AA;  75572 MW;  7FA77EF52971FFEC CRC64;
     MGASYEVRGQ VAVITLNNPP VNGLGHATRK AVAEGVEQAE NDAAIKAIVI TGAGRAFSGG
     ADIREFGSPK ALAEPNLGSL INRVESCAKP VVAAIHSVAM GGGLELALGC HYRVTAPGAK
     IALPEVKLGL LPGAGGTQRL PRALGVEPAL NMIVSGEPVN SELLAQVPGQ VLFQKVIDGD
     LLDGAVSYAL EIADKRPLPR VRDLKAQHPE AQAFFQFARN TVGALSKNFP APLQCVETVA
     NAVTMKFEDG MRAEREAFGL LMLTPESKAL RHAFFAERAA SKIPDVPEDT PLRKIEKVAI
     IGAGTMGGGI AMNFLNAGIP VVILEMKQEA LDRGLATIRK NYEAQVKKGK LKEDKYVQRM
     SLLHSTLNYA DIGDADLVIE AVFEDIGVKE QVFKQLDEVM KPGAILASNT STLDVDKIAS
     FTKRPQDVIG THFFSPANVM KLLEVVRGAA TAKDVLATVM ALGKKIRKTC VVSGVCDGFI
     GNRMIEQYSR QAGFLLEEGC TPQQVDKAAE RFGFAMGPFR MGDLAGNDVG WYIRKRRYLE
     KPDLRYSKTA DLLCEMGRFG QKTGAGWYDY QAGKRDAIPS KTVVEMIEMH RAALGIAPRK
     ISDEEIVQRL VFALVNEGAK ILEEGIALRA SDIDMVYLTG YGFPLWRGGP MCYADTVGLY
     NVVQAMKRFA KNPHDDGKFW EPAPLLARLA DQDKSFNE
//
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