ID A0A248TM52_9BACI Unreviewed; 716 AA.
AC A0A248TM52;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CKF48_19360 {ECO:0000313|EMBL:ASV69276.1};
OS Cytobacillus kochii.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Cytobacillus.
OX NCBI_TaxID=859143 {ECO:0000313|EMBL:ASV69276.1, ECO:0000313|Proteomes:UP000215137};
RN [1] {ECO:0000313|EMBL:ASV69276.1, ECO:0000313|Proteomes:UP000215137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BDGP4 {ECO:0000313|EMBL:ASV69276.1,
RC ECO:0000313|Proteomes:UP000215137};
RA Wan K.H., Yu C., Park S., Hammonds A.S., Booth B.W., Celniker S.E.;
RT "Complete Genome Sequence of Bacillus kochii Oregon-R-modENCODE STRAIN
RT BDGP4, isolated from Drosophila melanogaster gut.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; CP022983; ASV69276.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A248TM52; -.
DR KEGG; bko:CKF48_19360; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000215137; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ASV69276.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000215137};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..140
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 716 AA; 81710 MW; A643483F830885EE CRC64;
MKLIIAEKPD QGATLASVFP KKKHQGYIEI LPNPILTDGG FITWAIGHLC QLSPPEVYNT
TWKKWTLDTL PLLPNQFQHE VSKDKIKQFQ VIKKLLSHPE VNEVIHAGDA GREGELIIRN
ILRQAKSNLP MKRLWISSLT PNAIKKGFQQ LLDEEDTRNL FFEAYTRSCA DWIVGMNASR
LYTLLLQQKG FSDVFSVGRV QTPTLALIVK KELEIESFVS EPFWEVEATF KITGKKYKGK
WEDKGNSRIM DSALAEKIAL FCQGKEATIA DIKKEKKEFL PPQLYNLSAL QAEANRRYKF
SPKKTLDIVQ KLYQKGWVSY PRSDSRHITT EEANTLPQIL ARYEKIKDYE DFFPLPFSSI
IQNKRYVDEK KVTDHYAIIP TEQIPDFSKL ASEEKKLYDL IAKSVIAAHH KKAIIEYSTI
RTLVDERAMF ISKGKVIVDQ GYRQVISPVE KDKDVNLPLL DKGDKGITEK TEVKESKTQP
PKRYTEGQLI TLMKTAGKHI DDKELEQVLT QTEGLGTEAT RAGIITMLKD RGYIDVKKNI
VYATSKAKVL IIAVGKEILA SPEMTAKWEQ RLKQISKGEA SPKQFMDQTS QMVHHLIAAT
KEVTNEWIFS EEDKQQFIPK TFKKKRQSPL GNCQLCDGQV VDKGKFFGCS NYQKKNCTFT
LSKKILGKSM TQKIVKQLLK SGETDVLEGF QGKDKLFAAA LVWDKKENKI KFKFPT
//
