ID A0A248YL56_9ACTN Unreviewed; 798 AA.
AC A0A248YL56;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Amino acid adenylation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CIK06_08950 {ECO:0000313|EMBL:ASW54292.1};
OS Plantactinospora sp. KBS50.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Plantactinospora.
OX NCBI_TaxID=2024580 {ECO:0000313|EMBL:ASW54292.1, ECO:0000313|Proteomes:UP000216795};
RN [1] {ECO:0000313|EMBL:ASW54292.1, ECO:0000313|Proteomes:UP000216795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBS50 {ECO:0000313|EMBL:ASW54292.1,
RC ECO:0000313|Proteomes:UP000216795};
RA Juboi H., Hwang S.S., Yeo T.C., Nissom P.M.;
RT "Genome sequencing and analysis of secondary metabolite biosynthetic
RT capabilities of Plantactinospora sp. KBS50.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP022961; ASW54292.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A248YL56; -.
DR KEGG; plk:CIK06_08950; -.
DR OrthoDB; 3406074at2; -.
DR Proteomes; UP000216795; Chromosome.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000216795}.
FT DOMAIN 31..142
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 219..315
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
FT DOMAIN 420..645
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 702..775
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 379..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 84506 MW; 4B34A54D713140B8 CRC64;
MSQTVEYPPG EWNATDHPYR DDIVPAQLIL EAARRAPDAP AVLDAGGPVY TYGELVAAAG
RLARLLHERG VGPGDYVGVV GRHRPDTVVA LVAVALSGAT FVPCHPDWPP NRLGYVLSST
GARCLVGGIA DLARVDTWPP VAPGLTDLVA LDVDADTPPL LPDRERVARR WDAAVAAADP
VAAAGLTLPG GHRHTGADLD AYAAHVAGLV LAEQPSTVLE IGFGSGAVLR RVAPQVDLYA
GLDPAEQAVR AGVAWAKDEG IFADLVRGFA DEVAELLPGS YDVAVLAGTV THFPGVRYLR
ATLDRLAGVV RPGGAVVVAD VVPPGAAPAP GLLTLPAEFF ATLDAGTWSS IEVRPREGVP
GLPAELANRY DVVLRRAEAP AATTAGPDTT GPDTTGPATT GSAGLRVWTR RDVQRRAGHL
SPRGRPGDIA YVIFTSGSTG RPKGVTVSNT ALVNMLEWVT AEFGVGPADR LLQVTSFCFD
LSIYDIFGLL AAGGSIRLAS DEELTEPARV ADILISEPIT FWNSAPPLFA WVLPFLSTST
ADGPGRRSMR LMFLAGDWIA LSVPDEIRTI FPNVEIINYG GATETTVWST YFRIGAVDPA
WPSIPYGRPM WNARYYVLDE RRQPVPIGEP GDLYAAGTVL AVGYHGDPVL TAQRYVPDPF
VPGERMYACG DRGLWRPDGE LQFLGRVDHQ VKIRGFRVEL GEIESVIAAV EGVREAVVVT
VDAAGARSLA AFYTCRPPGA PVELVRTALV DRLPEYMVPA RLSQLDELPL TSNGKVDRAA
LGELARTQTA TDGPGGAA
//
