ID A0A248YP21_9ACTN Unreviewed; 1206 AA.
AC A0A248YP21;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CIK06_16735 {ECO:0000313|EMBL:ASW55466.1};
OS Plantactinospora sp. KBS50.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Plantactinospora.
OX NCBI_TaxID=2024580 {ECO:0000313|EMBL:ASW55466.1, ECO:0000313|Proteomes:UP000216795};
RN [1] {ECO:0000313|EMBL:ASW55466.1, ECO:0000313|Proteomes:UP000216795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBS50 {ECO:0000313|EMBL:ASW55466.1,
RC ECO:0000313|Proteomes:UP000216795};
RA Juboi H., Hwang S.S., Yeo T.C., Nissom P.M.;
RT "Genome sequencing and analysis of secondary metabolite biosynthetic
RT capabilities of Plantactinospora sp. KBS50.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP022961; ASW55466.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A248YP21; -.
DR KEGG; plk:CIK06_16735; -.
DR Proteomes; UP000216795; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000216795}.
FT DOMAIN 446..521
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 521..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1206 AA; 126892 MW; C2B00BAA44FA5C8B CRC64;
MVAVLLPRSV DAVVAWLAVL RAGAVYLPVD PGYPRERVDY LLADAGAVAV VTPDLLASVA
GPSEVDAPGA AGPDGAGPDG ADCAVPLPAA LDPRSGAYLI YTSGSTGRPK GVLIEHRSLA
NLFHHHRERL MAPVSDGRRL AVALSAATVF DTSWEGLLWL VAGHELHVLD DSTRRDPERF
VAYVNAHRID FLDVTPSLAG PLVEAGLLAD GGHRPALVAL GGEAADQRIW SALRSASGTV
GVNLYGPTEC TVDALLAWVG GSVFPVVGGP VGNARVYVLD GWLRPAVSGE LYVSGLPVGR
GYLGRSGLSA SRFVADPFRV GERMYRTGDV VRWVGGVLEF VGRVDDQVKV RGFRVEPGEV
AGVLGEHPGV SQVVVVGVGG RLVAYVVAAA GGSVGGLREW VAGRLPDYLV PSVVVGLDRL
PVTVSGKVDR RALPVPDLDD LVGDAAPRTP TEEILAGLFA DVLELSTVGT GDDFFALGGH
SLTATALAAR VRAVFGVALP LRAVFDAPTV AGLAAHLDRS PVGGAAPGAA GPELTRRDRP
DPVPVAPAQH RLWLHHQLNG PGPTYNVAFA LRLTGPLDVA ALRAALDDLL DRHESLRTVF
PTVEDRPVQR VLATARPRWQ FAECAEADLA GRLTEAAGYG FDLAGELLVR PHLFTLGPDR
HVLLLLLHHI VTDEWSEGRL VADLGTAYAA RAAGAAPDWA PLPIQYADYA LWQRDVLDEV
GQRQLDFWRT ALAGAPAELP LPADRPRPAA PGHAGGIVTF TVDAEAHRQA RELARRTGAT
VFMVVQAALA ALLSRLGAGT DIPLGSPVAG RVDQRLDALA GFFVNTLVLR ADLSGDPTFA
DLVGRVRRTD LAAFGNADVP FERVVEAVNP ERVLGRNPLF QVMVAFQHLP AGAPGLPGLA
TEPLPIDTGV AQFDLGVVVT EQDGVPGLRG VIEYSADRFD RRTAEDLAGR LARLLGAAAA
APERRVSELE LFSAAERRAL AADWQGGPSV GADRTLPELF AAQVRRHPDA PAVEDGAQTL
SYAELDRRTN RLARRLIAAG VGPDRLVMVL LPRCAALFET ELAVAKAGGG YLPVDPTYPA
QRVAALAADA APVLVVAGPD CTTVPPGCPC CAPRRWRRTA PTGPSPTRTG SRRCTPGTPR
TSSTPPGRPG RPRAWWCRTP ASPTWPPPSR GPGGSPPGTG SPSSRRPAST SPSPSWRSAC
WSGPPW
//
