ID A0A248YU60_9ACTN Unreviewed; 404 AA.
AC A0A248YU60;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:ASW57188.1};
GN ORFNames=CIK06_28150 {ECO:0000313|EMBL:ASW57188.1};
OS Plantactinospora sp. KBS50.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Plantactinospora.
OX NCBI_TaxID=2024580 {ECO:0000313|EMBL:ASW57188.1, ECO:0000313|Proteomes:UP000216795};
RN [1] {ECO:0000313|EMBL:ASW57188.1, ECO:0000313|Proteomes:UP000216795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBS50 {ECO:0000313|EMBL:ASW57188.1,
RC ECO:0000313|Proteomes:UP000216795};
RA Juboi H., Hwang S.S., Yeo T.C., Nissom P.M.;
RT "Genome sequencing and analysis of secondary metabolite biosynthetic
RT capabilities of Plantactinospora sp. KBS50.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP022961; ASW57188.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A248YU60; -.
DR KEGG; plk:CIK06_28150; -.
DR OrthoDB; 3399630at2; -.
DR Proteomes; UP000216795; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42813:SF7; ALCOHOL DEHYDROGENASE (ZN-DEPENDENT)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000216795};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..402
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 264..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 42651 MW; 0853EB113D43664E CRC64;
MRAVVYHGTG DISVDDVPEP KIEDPTDAIV RVTTAAICGT DLHFVRGTMP DMQAGRILGH
EGVGVVEEVG AQVGNFRPGD RVLISAVLGC GSCAYCRRGY FAQCEDINPY GPRAGTASFG
SPRPQGPFDG LQAEYARVPF AHTNLFRLPD GVSDAQAITL SDIYPTGYFG AVLANVTDGK
VTTVWGCGPV GQFAVVSAFQ RGASRVIAID GHADRLEKAR LHGAEVVDFN EVDPVEAVME
LTRGVGADCA VDAVGVDAES ARSGPAAAGV RKAAERNGAE QREISPEANP AGTDGHWKPG
DAPTQAQTWA VESLAKVGTL GVVGVYPAND RYFPIGTVLA RNLSVQAGNG NHPRYIPRLL
AMVESGRIDP ATVVTQHEPV TDALSAYREF DLRSPGWLKV ALHP
//
