ID A0A249DE86_LACRH Unreviewed; 354 AA.
AC A0A249DE86;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Sensor histidine kinase {ECO:0000256|PIRNR:PIRNR037431};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR037431};
GN ORFNames=BGK71_07730 {ECO:0000313|EMBL:ASX17307.1}, HWN39_07985
GN {ECO:0000313|EMBL:NVO88443.1};
OS Lacticaseibacillus rhamnosus (Lactobacillus rhamnosus).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=47715 {ECO:0000313|EMBL:ASX17307.1, ECO:0000313|Proteomes:UP000215843};
RN [1] {ECO:0000313|EMBL:ASX17307.1, ECO:0000313|Proteomes:UP000215843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LR5 {ECO:0000313|EMBL:ASX17307.1,
RC ECO:0000313|Proteomes:UP000215843};
RA Nam Y.-D., Kang J., Chung W.-H.;
RT "Complete genome sequence of Lactobacillus rhamnosus LR5.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NVO88443.1, ECO:0000313|Proteomes:UP000542889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QC {ECO:0000313|EMBL:NVO88443.1,
RC ECO:0000313|Proteomes:UP000542889};
RA Yi H., Jin M.;
RT "Lactobacillus rhamnosus QC,genome.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR037431};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR037431};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR037431}.
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DR EMBL; CP017063; ASX17307.1; -; Genomic_DNA.
DR EMBL; JABXWP010000010; NVO88443.1; -; Genomic_DNA.
DR RefSeq; WP_005711594.1; NZ_VRTQ01000002.1.
DR AlphaFoldDB; A0A249DE86; -.
DR GeneID; 69832135; -.
DR Proteomes; UP000215843; Chromosome.
DR Proteomes; UP000542889; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR017202; LiaS/VraS.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR PIRSF; PIRSF037431; STHK_LiaS; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR037431};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037431};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR037431};
KW Membrane {ECO:0000256|PIRNR:PIRNR037431, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037431};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037431};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR037431}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..349
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 186..213
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 354 AA; 39671 MW; 433882D518F425B3 CRC64;
MRRRMLVGFF MILLVWTLLV EACLVFMLAK VTHHDFLRLL LANVLSAPLL VYLLIGALLI
SSGATVIVLW RQRVVRSQLD SRLAQLNAGQ YQAPIFNRSQ QAEAALGKQP AALLEALRQK
MIRLQREIER YSNTPVRFSG ETREAILTGE RHRLARELHD SVSQQLFAAM MMLSALRSVA
ARDPKQEALN KQLDTIQKVI NEAQAEMRAL LLHLRPTNLE GKSLKQGIIQ LLKELQTKIT
IKITWQLDDI QLNAAAEDNL FRIVQELLSN TLRHAKADSL EVYLKRLQDM VILRMVDDGV
GFDPKETSSN GNYGLANIKE RAAAMGGTAK VVSVVGQGTS VEVRVPLSKD VAHD
//
