ID A0A249E0P6_9GAMM Unreviewed; 359 AA.
AC A0A249E0P6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147};
DE EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
GN ORFNames=BA172_01435 {ECO:0000313|EMBL:ASX27348.1};
OS Candidatus Portiera aleyrodidarum MED (Bemisia tabaci).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Zymobacter group; Portiera.
OX NCBI_TaxID=1163752 {ECO:0000313|EMBL:ASX27348.1, ECO:0000313|Proteomes:UP000215611};
RN [1] {ECO:0000313|Proteomes:UP000215611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEAM1 {ECO:0000313|Proteomes:UP000215611};
RA Chen W., Hasegawa D.K.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ASX27348.1, ECO:0000313|Proteomes:UP000215611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEAM1 {ECO:0000313|EMBL:ASX27348.1,
RC ECO:0000313|Proteomes:UP000215611};
RA Kaur N., Kliot A., Pinheiro P.V., Luan J., Zheng Y., Liu W., Sun H.,
RA Yang X., Xu Y., Luo Y., Kruse A., Fisher T.W., Nelson D.R., Elimelech M.,
RA MacCoss M., Johnson R., Cohen E., Hunter W.B., Brown J.K., Jander G.,
RA Cilia M., Douglas A.E., Ghanim M., Simmons A.M., Wintermantel W.M.,
RA Ling K.-S., Fei Z.;
RT "The genome of whitefly Bemisia tabaci, a global crop pest, provides novel
RT insights into virus transmission, host adaptation and insecticide
RT resistance.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC Evidence={ECO:0000256|ARBA:ARBA00000913};
CC -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC phenylpyruvate from prephenate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004741}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP016304; ASX27348.1; -; Genomic_DNA.
DR RefSeq; WP_014895058.1; NZ_CP016304.1.
DR AlphaFoldDB; A0A249E0P6; -.
DR GeneID; 66280015; -.
DR KEGG; paly:O3E_00905; -.
DR OrthoDB; 9802281at2; -.
DR UniPathway; UPA00120; UER00203.
DR UniPathway; UPA00121; UER00345.
DR Proteomes; UP000215611; Chromosome.
DR GO; GO:0004106; F:chorismate mutase activity; IEA:UniProtKB-EC.
DR GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046417; P:chorismate metabolic process; IEA:InterPro.
DR GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04905; ACT_CM-PDT; 1.
DR CDD; cd13630; PBP2_PDT_1; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.20.59.10; Chorismate mutase; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR InterPro; IPR036263; Chorismate_II_sf.
DR InterPro; IPR036979; CM_dom_sf.
DR InterPro; IPR001086; Preph_deHydtase.
DR InterPro; IPR018528; Preph_deHydtase_CS.
DR PANTHER; PTHR21022; PREPHENATE DEHYDRATASE P PROTEIN; 1.
DR PANTHER; PTHR21022:SF19; PREPHENATE DEHYDRATASE-RELATED; 1.
DR Pfam; PF00800; PDT; 1.
DR PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF48600; Chorismate mutase II; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Phenylalanine biosynthesis {ECO:0000256|ARBA:ARBA00023222}.
FT DOMAIN 88..261
FT /note="Prephenate dehydratase"
FT /evidence="ECO:0000259|PROSITE:PS51171"
FT DOMAIN 273..352
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT SITE 254
FT /note="Essential for prephenate dehydratase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ SEQUENCE 359 AA; 41307 MW; 7570677077F1039D CRC64;
MNKKFKPYIK YIGNIDYQIL KLISHRAKLV SQIQLADDKQ NCSYNNGHED RYFYSIKTSN
KGPLSNKVLS KIFKSIVSAC LKFKKKSQVA YLGPEGTFTQ QAVLKYFGKS IKSIPVKDVF
RTIENKIYNY GVVPVENSTE GIVNNTFDSF ISSNLKICGE IILSIHHHLL IDKQNINKNI
DKIYSHQQSF SQCRDWLKNN YPNAKKIAVA SNAEASNLTQ YKKNSAAIAG DLAASYYSLI
KLAKNIEDRI NNYTRFLILS DKDVAPTGYD KTYLMIYINN QIGSFYLLIE PFYRYNINIL
RLTTRPAPEN KGVWNYIIFL EIKGHRKSKL VEKTLEEIYL RGAELKILGS FPEQLTKRI
//
