ID A0A249KGA5_9ACTN Unreviewed; 1078 AA.
AC A0A249KGA5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A1sIA56_02655 {ECO:0000313|EMBL:ASY15821.1};
OS Candidatus Planktophila sulfonica.
OC Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC Candidatus Nanopelagicaceae; Planktophila.
OX NCBI_TaxID=1884904 {ECO:0000313|EMBL:ASY15821.1, ECO:0000313|Proteomes:UP000217215};
RN [1] {ECO:0000313|EMBL:ASY15821.1, ECO:0000313|Proteomes:UP000217215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS-IA-56 {ECO:0000313|EMBL:ASY15821.1};
RA Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT "High microdiversification within the ubiquitous acI lineage of
RT Actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP016773; ASY15821.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A249KGA5; -.
DR KEGG; psuf:A1sIA56_02655; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000217215; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000217215};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1078 AA; 117674 MW; F75355ABF9BBF5F6 CRC64;
MSFIHLRTAS AYSLKYGTTQ PRDLVARASE LEMPALALTD RDGMAGAIRF TKACVSHGIA
PIIGINLPIR IGDLSGTLPR VTVLAHGDGG WRSLVRLYTG LQMNSLDRTA VLTPELLEKF
SEYTSNLHLL HGPESPVSQA LATHRFDAAL DIFNQTRDLF ADHAIECVSH LVAGSGPRST
AHAARSLIFA RDNDIDAVIT NAVRMRDRAD GPVADVLDCA RQLVPLHPRN VERRNSEAFL
KSSDEMIALA AEISRAAGER TPRALLKTTR QWAERAVLSP HRDIGLGGIH LPEPHVVGAD
SPAAMRALLR TRSEAGINWR YNDGATIAKA RARLDDELAI VATLGYESYF LTVADITDMA
RAADIRVAAR GSGAGSLICH LLGISGVDPM EHGLLMERFC SPLRRALPDI DIDVESARRL
EIYEMVFKRY GAQDWSKPGL VSRCATVAMV DTYRARNAIR DAGAALGMPA MEIDLLAKSM
PHIRAGNIDA ALNSLPELKN LNTSAPLTRA TIALAARLDG LPRHLAMHPC AMVLSDAAFL
DRAPVQINAG GFPMVEFDKD DVEDIGLLKL DILGVRMQSA IAHAVHEIKR VEEKEIDIDA
VALDDLDTYQ LIQSTRTLGI FQVESPGQRE LVGKLEPRTF NDLIIDISLF RPGPVKSDMI
RPFLEARHGF SPAQIIHPDL LPILSETEGV VVFHEQVISI ISVMTGISLA AADEKRRALG
DRAGQQEVCD WFFPAATERG YELKVITEIW DVLRAFASFG FCKAHAAAFA LPTYQSAWLK
THHPAAFIAG VLTHDPGMYP KRLLLDEARQ MGVGIAPLDI NKSSIDYHVE RTLDGDAIRI
AFSTVAGISD KEITSIIAGQ PYIDLADFYR RSGASVPVIE NLIMTGAFDS VHTNQRDLLL
HFSDLQKSPV AHLPGSQLTF GFAAPALESS GLQPLNTAEK VRSEVERLGM DVTQHMLSFY
APFLNAIGAV KSSDLLSHRS KSSVLVAGVK VALQTPPVRS GRRVIFLTLD DGYGCSDSTF
FPDAQVDHAS TLYSTSLLLV RGETRRTGAR GISIRATAVW DLRLAYEKWR SQTDSVAI
//